2,2'-THIODIACETAMIDE

Base Information

• Chemical Name: 2,2'-THIODIACETAMIDE
• CAS No.: 14618-65-6
• Molecular Formula: C4H8 N2 O2 S
• Molecular Weight: 148.186
• Hs Code.: 2930909090
• European Community (EC) Number: 238-657-2
• NSC Number: 82327
• UNII: G4Y5Q1UXX2
• DSSTox Substance ID: DTXSID30163293
• Nikkaji Number: J54.122B
• Wikidata: Q27278754
• ChEMBL ID: CHEMBL171496
• Mol file: 14618-65-6.mol

Synonyms:2,2'-Thiodiethanamide;NSC 82327; Thiobisacetamide; Thiodiacetamide; Thiodiglycolamide

Chemical Property of 2,2'-THIODIACETAMIDE

Chemical Property:

• Melting Point: 172-176℃
• Boiling Point: 436.9°Cat760mmHg
• PKA: 15.30±0.40(Predicted)
• Flash Point: 218°C
• PSA: 111.48000
• Density: 1.345g/cm³
• LogP: 0.09080
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 148.03064868
• Heavy Atom Count: 9
• Complexity: 112

Purity/Quality:

98%min ^*data from raw suppliers

2,2'-THIOBISACETAMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 22-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)N)SCC(=O)N

Technology Process of 2,2'-THIODIACETAMIDE

There total 5 articles about 2,2'-THIODIACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

dimethyl thiodiglycolate (16002-29-2) → thiodiglcollic acid bis-amide (14618-65-6)

Guidance literature:

With ammonium hydroxide; In methanol; at 60 ℃; for 4h;

Reference yield:

diethyl thioglycolate (925-47-3) → thiodiglcollic acid bis-amide (14618-65-6)

Guidance literature:

With ammonia; In ethanol;

Reference yield:

2,2'-thiodiethanoyl chloride (7646-91-5) → thiodiglcollic acid bis-amide (14618-65-6)

Guidance literature:

With ammonia; In water; Heating;

DOI:10.1039/a900830f

upstream raw materials:

Chloroacetamide

diethyl thioglycolate

dimethyl thiodiglycolate

2,2'-thiodiethanoyl chloride

Downstream raw materials:

2-[(cyanomethyl)thio]acetonitrile

Refernces

• 1、 Kumar, Anil,Tilak, B. D.. "Esters of Thiodiglycollic and Thiodipropionic Acids and 2,5-Dicarboxy-3,4-dihydroxythiophene as Potential Slow Acting Anticancer Agents". . p. 880 - 882. Retrieved 2007/10/02.