2,2-dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone

Base Information

• Chemical Name: 2,2-dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone
• CAS No.: 169295-45-8
• Molecular Formula: C₁₅H₂₀O₃
• Molecular Weight: 248.322
• Mol file: 169295-45-8.mol

Synonyms:2,2-dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone

Chemical Property of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone

There total 4 articles about 2,2-dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dimethylketene (598-26-5) + 3-(2,5-Dimethylphenoxy)-propionaldehyde (164917-45-7) → 2,2-dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone (169295-45-8)

Guidance literature:

With zinc(II) chloride; In ethyl acetate; at 4 ℃; for 30h;

Reference yield: 75.0%

dimethylketene (598-26-5) + diethyl ether (60-29-7,927820-24-4) + 3-(2,5-Dimethylphenoxy)-propionaldehyde (164917-45-7) → 2,2-dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone (169295-45-8)

Guidance literature:

With boron trifluoride; In tetrahydrofuran;

Reference yield:

2,5-Dimethylphenol (95-87-4) → 2,2-dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone (169295-45-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / aq. NaOH, tetrabutylammonium hydroxide / 24 h / Heating

2: 90 percent / aq. p-TsOH / ethyl acetate / 60 °C

3: 90 percent / ZnCl₂ / ethyl acetate / 30 h / 4 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydroxide; toluene-4-sulfonic acid; zinc(II) chloride; In ethyl acetate;

upstream raw materials:

dimethylketene

3-(2,5-Dimethylphenoxy)-propionaldehyde

2,5-Dimethylphenol

diethyl ether

Downstream raw materials:

gemfibrozil

Refernces

• 1、 -. "Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids". . . Retrieved 2008/06/13.