Technology Process of 1,3-bis(4-chlorophenyl)-2-propanamine
There total 4 articles about 1,3-bis(4-chlorophenyl)-2-propanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,3-bis(4-chlorophenyl)-2-nitro-1-propene;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran; benzene;
for 3h;
Reflux;
With
hydrogenchloride;
In
tetrahydrofuran; water; benzene;
With
sodium hydroxide;
In
water;
DOI:10.1016/j.bmc.2010.11.054
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; silica gel / dichloromethane; isopropyl alcohol / 0.33 h / 20 °C
2: potassium fluoride; N,N-dimethylammonium chloride / toluene / 24 h / Reflux
3: lithium aluminium tetrahydride / tetrahydrofuran; benzene / 3 h / Reflux
With
potassium fluoride; sodium tetrahydroborate; lithium aluminium tetrahydride; N,N-dimethylammonium chloride; silica gel;
In
tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene; benzene;
2: Henry reaction;
DOI:10.1016/j.bmc.2010.11.054
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium fluoride; N,N-dimethylammonium chloride / toluene / 24 h / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran; benzene / 3 h / Reflux
With
potassium fluoride; lithium aluminium tetrahydride; N,N-dimethylammonium chloride;
In
tetrahydrofuran; toluene; benzene;
1: Henry reaction;
DOI:10.1016/j.bmc.2010.11.054
