Technology Process of 1-diazo-3-(2-oxo-2-phenylethyl)hexane-2,5-dione
There total 3 articles about 1-diazo-3-(2-oxo-2-phenylethyl)hexane-2,5-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) LDA / 1.) THF, 25 deg C, 5 h, 2.) 25 deg C, 12 h
2: 1.) O3, 2.) Me2S / 1.) -78 deg C, 2.) room temperature, 18 h
3: 1.) KOH, 2.) methyl chloroformate, Et3N / 1.) MeOH, H2O, room temperature, 3 h, 2.) Et2O, room temperature, 1 h, 3.) 0 deg C -> room temperature, overnight
With
potassium hydroxide; dimethylsulfide; ozone; triethylamine; methyl chloroformate; lithium diisopropyl amide;
DOI:10.1021/jo951576n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) LDA / 1.) THF, 25 deg C, 5 h, 2.) 25 deg C, 12 h
2: 1.) O3, 2.) Me2S / 1.) -78 deg C, 2.) room temperature, 18 h
3: 1.) KOH, 2.) methyl chloroformate, Et3N / 1.) MeOH, H2O, room temperature, 3 h, 2.) Et2O, room temperature, 1 h, 3.) 0 deg C -> room temperature, overnight
With
potassium hydroxide; dimethylsulfide; ozone; triethylamine; methyl chloroformate; lithium diisopropyl amide;
DOI:10.1021/jo951576n
- Guidance literature:
-
With
potassium hydroxide; triethylamine; methyl chloroformate;
Yield given. Multistep reaction;
1.) MeOH, H2O, room temperature, 3 h, 2.) Et2O, room temperature, 1 h, 3.) 0 deg C -> room temperature, overnight;
DOI:10.1021/jo951576n