Bialamicol

Base Information

• Chemical Name: Bialamicol
• CAS No.: 493-75-4
• Molecular Formula: C₂₈H₄₀N₂O₂
• Molecular Weight: 436.638
• UNII: TA5NM093QJ
• DSSTox Substance ID: DTXSID60197763
• Nikkaji Number: J6.070D
• Wikidata: Q27289865
• NCI Thesaurus Code: C83555
• ChEMBL ID: CHEMBL1197792
• Mol file: 493-75-4.mol

Synonyms:BIALAMICOL;Camoform;Biallylamicol;493-75-4;Bialamicolum;Bialamicol hydrochloride;GNF-Pf-4303;Bialamicol [INN:BAN];CT 871;Bialamicolum [INN-Latin];UNII-TA5NM093QJ;Camoform hydrochloride;TA5NM093QJ;PAA-701;2-(diethylaminomethyl)-4-[3-(diethylaminomethyl)-4-hydroxy-5-prop-2-enylphenyl]-6-prop-2-enylphenol;Biallylamicol hydrochloride;PAA 701 dihydrochloride;Biallylamicol dihydrochlorde;PAA 701;SN 6771;CAM-807;CI 301;3,3'-Bis((diethylamino)methyl)-5,5'-di-2-propenyl-(1,1'-biphenyl)-4,4'-diol;5,5'-Diallyl-3,3'-bis(diethylaminomethyl)-4,4'-diphenyldiol;C28H40N2O2;5,5'-Diallyl-alpha,alpha'-bis(diethylamino)-n,n'-bitolyl-4,4'-diol;5,5'-Diallyl-.alpha.,.alpha.'-bis(diethylamino)-m,m'-bitolyl-4,4'-diol;C28H40N2O2.2ClH;Bialamicol hydrochloride [USAN];NSC6386;CI-301;C28-H40-N2-O2.2Cl-H;(1,1'-Biphenyl)-4,4'-diol, 3,3'-bis((diethylamino)methyl)-5,5'-di-2-propenyl-;[1,1'-Biphenyl]-4,4'-diol, 3,3'-bis[(diethylamino)methyl]-5,5'-di-2-propenyl-;(1,1'-Biphenyl)-4,4'-diol, 3,3'-bis((diethylamino)methyl)-5,5'-di-2-propenyl-, 2hcl;m,m'-Bitolyl-4,4'-diol, 5,5'-diallyl-.alpha.,.alpha.'-bis(diethylamino)-, dihydrochloride;BIALAMICOL [MI];BIALAMICOL [INN];BIALAMICOL [WHO-DD];SCHEMBL483160;CHEMBL1197792;DTXSID60197763;CHEBI:135712;SN-6771PAA-701;AKOS024263956;SN-6771;NCI60_012898;Q27289865;3,3'-Diallyl-5,5'-bis[(diethylamino)methyl][1,1'-biphenyl]-4,4'-diol #;6,6'-DIALLYL-.ALPHA.,.ALPHA.'-BIS(DIETHYLAMINO)-4,4'-BI-O-CRESOL;(1,1'-BIPHENYL)-4,4'-DIOL, 3,3'-BIS((DIETHYLAMINO)METHY)-5,5'-DI-2-PROPENYL;2-allyl-4-[3-allyl-5-(diethylaminomethyl)-4-hydroxy-phenyl]-6-(diethylaminomethyl)phenol

Chemical Property of Bialamicol

Chemical Property:

• Vapor Pressure: 6.95E-11mmHg at 25°C
• Boiling Point: 506.6°Cat760mmHg
• Flash Point: 206.6°C
• PSA: 46.94000
• Density: 1.04g/cm³
• LogP: 5.90540
• XLogP3: 6.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 13
• Exact Mass: 436.308978523
• Heavy Atom Count: 32
• Complexity: 498

Purity/Quality:

98%Min ^*data from raw suppliers

BIALAMICOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CC1=CC(=CC(=C1O)CC=C)C2=CC(=C(C(=C2)CN(CC)CC)O)CC=C
• Uses: Anti-amebic.

Technology Process of Bialamicol

There total 3 articles about Bialamicol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3,3'-diallylbiphenyl-4,4'-diol (6942-01-4) + diethylamine (109-89-7) → 3,3'-diallyl-5,5'-bis(diethylaminomethyl)biphenyl-4,4'-diol (493-75-4)

Guidance literature:

With ethanol;

DOI:10.1021/ja01214a008

Reference yield:

4,4'-Dihydroxybiphenyl (92-88-6) → 3,3'-diallyl-5,5'-bis(diethylaminomethyl)biphenyl-4,4'-diol (493-75-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / K₂CO₃ / acetone / 48 h / Heating

2: 65 percent / N,N-diethylaniline / 3 h / Heating

3: ethanol / 1 h / Heating

With potassium carbonate; N,N-diethylaniline; In ethanol; acetone;

DOI:10.1055/s-1996-4262

Reference yield:

4,4′-bis(allyloxy)-1,1′-biphenyl (41481-62-3) → 3,3'-diallyl-5,5'-bis(diethylaminomethyl)biphenyl-4,4'-diol (493-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / N,N-diethylaniline / 3 h / Heating

2: ethanol / 1 h / Heating

With N,N-diethylaniline; In ethanol;

DOI:10.1055/s-1996-4262

upstream raw materials:

formaldehyd

3,3'-diallylbiphenyl-4,4'-diol

diethylamine

4,4'-Dihydroxybiphenyl

Refernces