3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE

Base Information

• Chemical Name: 3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE
• CAS No.: 2538-50-3
• Molecular Formula: C10H14N.ClH
• Molecular Weight: 199.68
• Mol file: 2538-50-3.mol

Synonyms:1-Propanone,3-(methylamino)-1-phenyl-, hydrochloride (9CI);Propiophenone,3-(methylamino)-, hydrochloride (6CI,7CI,8CI);3-(N-Methylamino)propiophenone hydrochloride;3-Methylaminopropiophenone;

Chemical Property of 3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.00534mmHg at 25°C
• Melting Point: 139-141 °C(Solv: acetone (67-64-1))
• Refractive Index: 1.515
• Boiling Point: 274.7°C at 760 mmHg
• Flash Point: 114.1°C
• PSA: 29.10000
• Density: 1.002g/cm³
• LogP: 2.67170
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

3-(Methylamino)-1-phenylpropan-1-oneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Methylamino)-1-phenylpropan-1-one Hydrochloride can be used for nontoxic non-irritating wood preservative for toys or teaching appliances.

Technology Process of 3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE

There total 3 articles about 3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methylamine hydrochloride (593-51-1) + acetophenone (98-86-2) → β-Methylaminoethyl phenyl ketone hydrochloride (2538-50-3)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 110 ℃; for 20h; Sealed tube;

Reference yield: 52.0%

→ β-Methylaminoethyl phenyl ketone hydrochloride (2538-50-3)

Guidance literature:

Reference yield:

3-(dimethylamino)propiophenone hydrochloride (879-72-1) → β-Methylaminoethyl phenyl ketone hydrochloride (2538-50-3)

Guidance literature:

upstream raw materials:

3-(dimethylamino)propiophenone hydrochloride

formaldehyd

methylamine hydrochloride

acetophenone

Downstream raw materials:

3,3’-(methylazanediyl)bis(1-phenylpropan-1-one)

Methyl(2-methyl-3-oxo-1-butyl)(2-benzoylethyl)amin

Methyl(2-methyl-2-benzoyl-1-propyl)(2-benzoylethyl)amin

3-methylamino-1-phenylpropan-1-ol

Refernces

• 1、 -. "A method for preparing optically active 3-amino-1-phenylpropanol derivatives as an intermediate and a method for preparing optically active pharmaceutical products using the same". Paragraph 0117-0120. . Retrieved 2016/11/09.
• 2、 Liu, Duan,Gao, Wenzhong,Wang, Chunjiang,Zhang, Xumu. "Practical synthesis of enantiopure γ-amino alcohols by rhodium-catalyzed asymmetric hydrogenation of β-secondary-amino ketones". . p. 1687 - 1689. Retrieved 2007/10/03.