Technology Process of 3,4-methylenedioxy-2,4',5-trimethoxy-3'-O-t-butyldimethylsilylstilbene
There total 3 articles about 3,4-methylenedioxy-2,4',5-trimethoxy-3'-O-t-butyldimethylsilylstilbene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
<3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl>triphenylphosphonium bromide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
4,7-dimethoxy-benzo[1,3]dioxole-5-carbaldehyde;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 10h;
optical yield given as %de;
Inert atmosphere;
DOI:10.1021/np1004278
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrabutylammomium bromide; potassium hydroxide / 0.67 h / 100 °C
2.1: pyridine; ozone / methanol; chloroform / -15 - 0 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
3.2: 10 h / 20 °C / Inert atmosphere
With
pyridine; n-butyllithium; tetrabutylammomium bromide; ozone; potassium hydroxide;
In
tetrahydrofuran; methanol; hexane; chloroform;
3.1: Wittig reaction / 3.2: Wittig reaction;
DOI:10.1021/np1004278
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine; ozone / methanol; chloroform / -15 - 0 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 10 h / 20 °C / Inert atmosphere
With
pyridine; n-butyllithium; ozone;
In
tetrahydrofuran; methanol; hexane; chloroform;
2.1: Wittig reaction / 2.2: Wittig reaction;
DOI:10.1021/np1004278