tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyprolinate

Base Information

• Chemical Name: tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyprolinate
• CAS No.: 166410-19-1
• Molecular Formula: C₂₃H₂₉NO₅S
• Molecular Weight: 431.553
• Mol file: 166410-19-1.mol

Synonyms:tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyprolinate

Chemical Property of tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyprolinate

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyprolinate

There total 1 articles about tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyprolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

tert-butyl (2S,4S)-N-para-toluenesulfonyl-3-benzylidene-4-hydroxyprolinate → tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyprolinate (166410-19-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 24h; Ambient temperature;

DOI:10.1016/0040-4020(95)00135-U

Reference yield: 98.0%

tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyprolinate (166410-19-1) → (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyproline

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1016/0040-4020(95)00135-U

Reference yield: 84.0%

methanesulfonyl chloride (124-63-0) + tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-hydroxyprolinate (166410-19-1) → tert-butyl (2S,3S,4S)-N-para-toluenesulfonyl-3-benzyl-4-oxymethanesulfonylprolinate

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; for 48h; Ambient temperature;

DOI:10.1016/0040-4020(95)00135-U

Refernces