Technology Process of 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate
There total 30 articles about 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate which
guide to synthetic route it.
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synthetic route:
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1040272-38-5
(1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-4-oxooxetane-2-carboxylate
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1040272-14-7
1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate
- Guidance literature:
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(1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-4-oxooxetane-2-carboxylate;
With
sodium methylate;
In
methanol;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
With
water; ammonium chloride;
In
methanol;
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1040272-38-5
(1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-4-oxooxetane-2-carboxylate
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1040272-14-7
1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate
- Guidance literature:
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With
methanol;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
DOI:10.1002/chem.200701998
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1040272-14-7
1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate
- Guidance literature:
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Multi-step reaction with 10 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: hydrogenchloride / methanol; water / 16 h / 25 °C / Inert atmosphere
3.1: ytterbium(III) triflate / dichloromethane / 48 h / 0 °C / Inert atmosphere
4.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 20 h / 25 °C / Inert atmosphere
5.1: chromium dichloride / water / 1 h / 25 °C / Inert atmosphere
6.1: hydrogen / palladium on activated charcoal / ethyl acetate / 6 h / 25 °C
7.1: toluene-4-sulfonic acid / dichloromethane / 0 - 25 °C / Inert atmosphere
8.1: sodium tetrahydroborate / methanol / -78 - 25 °C / Inert atmosphere
9.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / dichloromethane / 1 h / 23 °C / Inert atmosphere
9.2: 0.42 h / 23 °C / Inert atmosphere
10.1: sodium methylate / methanol / 0.17 h / 0 °C / Inert atmosphere
With
chromium dichloride; hydrogenchloride; sodium tetrahydroborate; 2,4,6-trichlorobenzoyl chloride; 2-iodoxybenzoic acid; hydrogen; sodium methylate; potassium hexamethylsilazane; toluene-4-sulfonic acid; triethylamine; ytterbium(III) triflate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;