3-Nitrophenylhydrazine hydrochloride

Base Information

• Chemical Name: 3-Nitrophenylhydrazine hydrochloride
• CAS No.: 636-95-3
• Molecular Formula: C₆H₈N₃O₂*Cl
• Molecular Weight: 189.601
• Hs Code.: 2928000090
• Mol file: 636-95-3.mol

Synonyms:Hydrazine,(3-nitrophenyl)-, monohydrochloride (9CI);Hydrazine, (m-nitrophenyl)-,hydrochloride (6CI,7CI,8CI);m-Nitrophenylhydrazine hydrochloride;

Chemical Property of 3-Nitrophenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: yellow crystalline powder
• Vapor Pressure: 0.000384mmHg at 25°C
• Melting Point: 210 °C (dec.)(lit.)
• Boiling Point: 317.5 °C at 760 mmHg
• Flash Point: 145.8 °C
• PSA: 83.87000
• Density: 1.419 g/cm³
• LogP: 2.97890
• Storage Temp.: Flammables area
• Solubility.: DMSO, Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 189.0305042
• Heavy Atom Count: 12
• Complexity: 145

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Nitrophenylhydrazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)[N+](=O)[O-])N[NH3+].[Cl-]
• Uses: 3-Nitrophenylhydrazine Hydrochloride acts as a reagent in the preparation of isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents, preparation of pyrazolobenzothiazines as inhibitors of hepatitis C virus replication.

Technology Process of 3-Nitrophenylhydrazine hydrochloride

There total 2 articles about 3-Nitrophenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-nitro-aniline (99-09-2) → 3-nitrophenylhydrazine hydrochloride (51516-96-2,636-95-3)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

Reference yield: 73.0%

SnCl2.H2O + 3-nitro-aniline (99-09-2) → 3-nitrophenylhydrazine hydrochloride (51516-96-2,636-95-3)

Guidance literature:

With sodium nitrite; In hydrogenchloride; water;

Reference yield: 100.0%

2,4-difluorophenyl carbonochloridate + 3-nitrophenylhydrazine hydrochloride (51516-96-2,636-95-3) → 2,4-difluorophenyl 2-(3-nitrophenyl)hydrazinecarboxylate (1169939-56-3)

Guidance literature:

With pyridine; In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃; for 1.5h;

upstream raw materials:

3-nitro-aniline

Downstream raw materials:

4-methoxy-benzaldehyde-(3-nitro-phenylhydrazone)

acetone-(3-nitro-phenylhydrazone)

4-Hydroxy-3-{1-[(3-nitro-phenyl)-hydrazono]-ethyl}-chromen-2-one

hydroxy-pyruvaldehyde bis-(3-nitro-phenylhydrazone)

Refernces

• 1、 Xu, Renbo,Xia, Rui,Luo, Ming,Xu, Xiaoyong,Cheng, Jiagao,Shao, Xusheng,Li, Zhong. "Design, synthesis, crystal structures, and insecticidal activities of eight-membered azabridge neonicotinoid analogues". . p. 381 - 390. Retrieved 2014/02/14.
• 2、 -. "COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES". . . Retrieved 2012/04/23.