2-([(4-CHLOROPHENYL)SULFONYL]AMINO)PROPANOIC ACID

Base Information

• Chemical Name: 2-([(4-CHLOROPHENYL)SULFONYL]AMINO)PROPANOIC ACID
• CAS No.: 59724-70-8
• Molecular Formula: C9H10 Cl N O4 S
• Molecular Weight: 263.702
• Mol file: 59724-70-8.mol

Synonyms:TIMTEC-BB SBB007373;AURORA 4525;CHEMBRDG-BB 5527786;AKOS BBS-00007615;2-(4-CHLORO-BENZENESULFONYLAMINO)-PROPIONIC ACID;2-([(4-CHLOROPHENYL)SULFONYL]AMINO)PROPANOIC ACID

Chemical Property of 2-([(4-CHLOROPHENYL)SULFONYL]AMINO)PROPANOIC ACID

Chemical Property:

• Vapor Pressure: 1.01E-08mmHg at 25°C
• Melting Point: 145-147°C
• Boiling Point: 445.6°C at 760 mmHg
• Flash Point: 223.3°C
• PSA: 91.85000
• Density: 1.465g/cm3
• LogP: 2.56310

Purity/Quality:

99%min ^*data from raw suppliers

2-([(4-CHLOROPHENYL)SULFONYL]AMINO)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-([(4-CHLOROPHENYL)SULFONYL]AMINO)PROPANOIC ACID

There total 1 articles about 2-([(4-CHLOROPHENYL)SULFONYL]AMINO)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-alanin (56-41-7,25191-17-7,18875-37-1) + 4-chlorobenzenesulfonyl chloride (98-60-2) → (S)-2-(4-chlorophenyl)sulfonylamino-propionic acid (59724-70-8)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; for 12h;

DOI:10.1021/acs.orglett.0c00918

Reference yield: 85.0%

(S)-2-(4-chlorophenyl)sulfonylamino-propionic acid (59724-70-8) + 3-amino-piperidine dihydrochloride (127294-75-1,138060-07-8,150395-91-8,334618-23-4) → (R)-3-aminopiperidine di(S)-2-(4-chlorophenyl)sulfonylamino-propionate

Guidance literature:

3-amino-piperidine dihydrochloride; With sodium hydroxide; In water; for 0.166667h;

(S)-2-(4-chlorophenyl)sulfonylamino-propionic acid; In water; at 22 - 40 ℃; for 2.5h;

Reference yield: 22.0%

(S)-2-(4-chlorophenyl)sulfonylamino-propionic acid (59724-70-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (S)-2-((4-chlorophenyl)sulfonamido)-N-methoxy-N-methylpropanamide

Guidance literature:

With 4-methyl-morpholine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00918

upstream raw materials:

L-alanin

4-chlorobenzenesulfonyl chloride

Refernces