3,5 - dibroMo - 6 - oxo - 6H - anthraisoxazole

Base Information

• Chemical Name: 3,5 - dibroMo - 6 - oxo - 6H - anthraisoxazole
• CAS No.: 82840-40-2
• Molecular Formula: C₁₄H₅Br₂NO₂
• Molecular Weight: 379.007
• Mol file: 82840-40-2.mol

Synonyms:3,5-dibromo-6-oxo-6H-anthra<1,9-cd>isoxazole

Chemical Property of 3,5 - dibroMo - 6 - oxo - 6H - anthraisoxazole

Chemical Property:

• Melting Point: 247-248 °C(Solv: acetic acid (64-19-7))
• Boiling Point: 551.7±50.0 °C(Predicted)
• PKA: -11.21±0.20(Predicted)
• Density: 2.023±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5 - dibroMo - 6 - oxo - 6H - anthraisoxazole

There total 8 articles about 3,5 - dibroMo - 6 - oxo - 6H - anthraisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

1-azido-2,4-dibromoanthraquinone → 3,5-dibromo-6-oxo-6H-anthra<1,9-cd>isoxazole (82840-40-2)

Guidance literature:

In toluene; at 80 ℃; for 6h;

Reference yield: 76.0%

1-amino-2, 4-dibromoanthraquinone (81-49-2) → 3,5-dibromo-6-oxo-6H-anthra<1,9-cd>isoxazole (82840-40-2)

Guidance literature:

1-amino-2,4-dibromoanthracene-9,10-dione; With sulfuric acid; NaNO₂; In water monomer; at 30 - 55 ℃; for 17h;

With Caswell No_. 744A; In water monomer; for 16h;

In toluene; at 70 ℃; for 12h;

Reference yield: 66.0%

1-amino-2,4-dibromoanthracene-9,10-dione → 3,5-dibromo-6-oxo-6H-anthra<1,9-cd>isoxazole (82840-40-2)

Guidance literature:

1-amino-2,4-dibromoanthracene-9,10-dione; With sulfuric acid; sodium nitrite;

With sodium azide; In toluene; Reflux;

DOI:10.1002/anie.201510866

upstream raw materials:

1-amino-2, 4-dibromoanthraquinone

1-amino-9,10-anthracenedione

5-hydroxynaphtho-1,4-quinone

1-hydroxyanthraquinone

Downstream raw materials:

3-Bromo-5-(3,5-dimethyl-phenylamino)-anthra[1,9-cd]isoxazol-6-one

3-Bromo-5-(3,4-dimethyl-phenylamino)-anthra[1,9-cd]isoxazol-6-one

Refernces

• 1、 -. "TARGETED BIFUNCTIONAL DEGRADERS". . . Retrieved 2021/04/17.
• 2、 -. "PROCESS OF PREPARING TYROSINE KINASE INHIBITOR". Page/Page column 18-19. . Retrieved 2017/03/21.