Technology Process of (S)-1-((2R,3S,4S)-1-Benzyl-3,4-bis-benzyloxy-pyrrolidin-2-yl)-ethane-1,2-diol
There total 16 articles about (S)-1-((2R,3S,4S)-1-Benzyl-3,4-bis-benzyloxy-pyrrolidin-2-yl)-ethane-1,2-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; N-methyl-2-indolinone; water;
In
1,4-dioxane;
at 60 ℃;
DOI:10.1055/s-2001-14593
- Guidance literature:
-
With
osmium(VIII) oxide; 4-methylmorpholine N-oxide;
In
1,4-dioxane; water;
for 24h;
Ambient temperature;
DOI:10.1016/0040-4039(90)87010-W
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: molecular sieves 4 Angstroem / diethyl ether / 20 °C
2.1: Et2O*BF3 / -78 - -40 °C
2.2: tetrahydrofuran; diethyl ether / -78 - 20 °C
3.1: 90 percent / pyridine; H2O / tetrahydrofuran / 20 °C
4.1: 85 percent / NaH; Bu4NI / tetrahydrofuran / 20 °C
5.1: 85 percent / TBAF supported on SiO2 / tetrahydrofuran / 20 °C
6.1: 95 percent / aq. LiOH / dioxane / Heating
7.1: 73 percent / Ph3P; CCl4; Et3N / dimethylformamide / 20 °C
8.1: 85 percent / NaH; Bu4NI / tetrahydrofuran / 20 °C
9.1: 65 percent / NMO; OsO4; H2O / dioxane / 60 °C
With
pyridine; tetrachloromethane; lithium hydroxide; osmium(VIII) oxide; N-methyl-2-indolinone; 4 A molecular sieve; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-14593