4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxy-benzamide

Base Information

• Chemical Name: 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxy-benzamide
• CAS No.: 7232-21-5
• Molecular Formula: C14H22ClN3O2^.HCl
• Molecular Weight: 336.262
• Hs Code.: 29242990
• Mol file: 7232-21-5.mol

Synonyms:Metoclopramide Base;4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxy-benzamide;AKOS015890642

Chemical Property of 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxy-benzamide

Chemical Property:

• Appearance/Colour: white solid
• Melting Point: 171-173 °C
• Boiling Point: 418.7 °C at 760 mmHg
• Flash Point: 207 °C
• PSA: 67.59000
• LogP: 3.77650
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility.: H2O: soluble
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 335.1167324
• Heavy Atom Count: 21
• Complexity: 300

Purity/Quality:

99% ^*data from raw suppliers

Metoclopramide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.[Cl-]
• Description: Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes. It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.
• Uses: Antiemetic;5-HT3 antagonist A D2DR inhibitor and an HTR3E inhibitor Dopamine D2 receptor antagonist. Antiemetic.
• Clinical Use: Nausea and vomiting
• Drug interactions: Potentially hazardous interactions with other drugs Ciclosporin: increased ciclosporin blood levels.