Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-but-3-ynyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-but-3-ynyl ester
• CAS No.: 128364-35-2
• Molecular Formula: C₁₇H₂₂O₄S
• Molecular Weight: 322.425
• Mol file: 128364-35-2.mol

Synonyms:Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-but-3-ynyl ester

Chemical Property of Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-but-3-ynyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-but-3-ynyl ester

There total 2 articles about Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-but-3-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-butyn-1-yl p-toluenesulfonate (23418-85-1) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-but-3-ynyl ester (128364-35-2)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) THF, hexane, -78 deg C, 30 min, 2) THF, -78 deg C, 2h;

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-but-3-ynyl ester (128364-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NEt₃ / CH₂Cl₂ / Ambient temperature

2: 1) BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) THF, -78 deg C, 2h

With n-butyllithium; triethylamine; In dichloromethane;

Reference yield: 50.0%

Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-but-3-ynyl ester (128364-35-2) → Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-butyl ester (57740-21-3)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; for 4h; under 2068.6 Torr;

upstream raw materials:

3-butyn-1-yl p-toluenesulfonate

cyclohexanone

p-toluenesulfonyl chloride

Downstream raw materials:

Toluene-4-sulfonic acid 4-(1-hydroxy-cyclohexyl)-butyl ester

Refernces