6-methoxy-5-phenoxy-[8]quinolylamine

Base Information

• Chemical Name: 6-methoxy-5-phenoxy-[8]quinolylamine
• CAS No.: 63460-36-6
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.299
• Mol file: 63460-36-6.mol

Synonyms:6-methoxy-5-phenoxy-[8]quinolylamine

Chemical Property of 6-methoxy-5-phenoxy-[8]quinolylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methoxy-5-phenoxy-[8]quinolylamine

There total 6 articles about 6-methoxy-5-phenoxy-[8]quinolylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-bromo-4-methoxyphenyl)acetamide (6943-73-3) → 6-methoxy-5-phenoxy-[8]quinolylamine (63460-36-6)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; acetic acid anhydride; nitric acid / 5 °C

2: arsenic (V)-oxide; sulfuric acid / 130 - 140 °C

3: 2-butoxy-ethanol

4: iron-powder; aqueous acetic acid

With arsenic(V) oxide; 2-Butoxyethanol; sulfuric acid; nitric acid; acetic anhydride; iron; acetic acid;

DOI:10.1021/ja01212a045

Reference yield:

N-(5-bromo-4-methoxy-2-nitrophenyl)acetamide (7357-66-6) → 6-methoxy-5-phenoxy-[8]quinolylamine (63460-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1: arsenic (V)-oxide; sulfuric acid / 130 - 140 °C

2: 2-butoxy-ethanol

3: iron-powder; aqueous acetic acid

With arsenic(V) oxide; 2-Butoxyethanol; sulfuric acid; iron; acetic acid;

DOI:10.1021/ja01212a045

Reference yield:

potassium phenolate (100-67-4) → 6-methoxy-5-phenoxy-[8]quinolylamine (63460-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-butoxy-ethanol

2: iron-powder; aqueous acetic acid

With 2-Butoxyethanol; iron; acetic acid;

DOI:10.1021/ja01212a045

upstream raw materials:

N-(3-bromo-4-methoxyphenyl)acetamide

N-(5-bromo-4-methoxy-2-nitrophenyl)acetamide

potassium phenolate

6-methoxy-8-nitroquinoline

Downstream raw materials:

N-[4-(6-methoxy-5-phenoxy-quinolin-8-ylamino)-pentyl]-phthalimide

N⁴-(6-methoxy-5-phenoxyquinolin-8-yl)pentane-1,4-diamine

Refernces

• 1、 Chen,Saggiomo,Tanabe,Verma,Nodiff. "Modifications of primaquine as antimalarials. I. 5 Phenoxy derivatives of primaquine". . p. 1107 - 1109. Retrieved 2007/10/05.