Multi-step reaction with 5 steps
1.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 0.5 h / 20 °C
2.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; tert-butylamine / ethyl acetate / -15 °C
2.2: 1 h / 70 °C
3.1: sodium methylate / methanol / 0 - 60 °C
3.2: 20 °C
4.1: ethanol / 14 h / 85 °C
5.1: trichlorophosphate / 45 °C
With
lithium hydroxide monohydrate; water; sodium methylate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; tert-butylamine; triethylamine; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate;