4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

Base Information

• Chemical Name: 4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide
• CAS No.: 1208342-20-4
• Molecular Formula: C₂₄H₁₈Cl₂F₃N₅O
• Molecular Weight: 520.341
• Mol file: 1208342-20-4.mol

Synonyms:4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

Chemical Property of 4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

There total 5 articles about 4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-(Aminomethyl)pyridine (3731-51-9) + 4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methylbenzoic acid (1208348-79-1) → 4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide (1208342-20-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

methyl 4-hydrazino-2-methylbenzoate (1208351-36-3) → 4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide (1208342-20-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / ethanol / 80 °C

2.1: water; sodium hydroxide / ethanol / 48 h / 20 °C

2.2: pH 3 - 4

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

methyl 4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methylbenzoate (1208348-80-4) → 4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide (1208342-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / ethanol / 48 h / 20 °C

1.2: pH 3 - 4

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

2-(Aminomethyl)pyridine

4-[5-amino-4-(3,5-dichlorophenyl)-3-trifluoromethylpyrazol-1-yl]-2-methylbenzoic acid

4-acetylamino-2-methylbenzoic acid

methyl 4-hydrazino-2-methylbenzoate

Downstream raw materials:

4-[4-(3,5-dichlorophenyl)-5-iodo-3-trifluoromethylpyrazol-1-yl]-2-methyl-N-pyridin-2-ylmethylbenzamide

Refernces