DL-INDOLE-3-LACTIC ACID

Base Information

• Chemical Name: DL-INDOLE-3-LACTIC ACID
• CAS No.: 832-97-3
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.213
• Hs Code.: 29339980
• Mol file: 832-97-3.mol

Synonyms:DL-INDOLE-3-LACTIC ACID;DL-B-3-INDOLELACTIC ACID;DL-3-(3-INDOLYL)-LACTIC ACID;DL-3-INDOLELACTIC ACID;3-(3-INDOLYL)LACTIC ACID;3-[3-INDOLYL]-2-HYDROXYPROPANOIC ACID;3-INDOLE-LACTIC ACID;(±)-alpha-hydroxy-1H-indole-3-propionic acid

Chemical Property of DL-INDOLE-3-LACTIC ACID

Chemical Property:

• Vapor Pressure: 9.8E-10mmHg at 25°C
• Melting Point: 145-146 °C(lit.)
• Boiling Point: 472.6°C at 760 mmHg
• Flash Point: 239.6°C
• PSA: 73.32000
• Density: 1.423g/cm³
• LogP: 1.15590
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

DL-Indole-3-lactic acid 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for preparation of:? ;Antibacterial agents1? ;Dietary sweetener2 Reactant for preparation of:Antibacterial agentsDietary sweetener

Technology Process of DL-INDOLE-3-LACTIC ACID

There total 14 articles about DL-INDOLE-3-LACTIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 2-hydroxy-3-(1H-indol-3-yl)propanoate (18372-16-2) → indole-3-lactic acid (832-97-3,1821-52-9)

Guidance literature:

With sodium hydroxide; In methanol; water; at 55 - 60 ℃; for 0.5h;

DOI:10.1002/jlac.198319830207

Reference yield: 72.0%

L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) → Indole-3-pyruvic acid (392-12-1) + indole-3-lactic acid (832-97-3,1821-52-9)

Guidance literature:

With formate dehydrogenase; oxygen; ammonium formate; NADH; In aq. phosphate buffer; at 21 ℃; for 7h; under 750.075 Torr; pH=7; stereoselective reaction; Enzymatic reaction;

DOI:10.1002/chem.201403195

Reference yield:

Indole-3-pyruvic acid (392-12-1) → indole-3-lactic acid (832-97-3,1821-52-9)

Guidance literature:

With ethanol; nickel; Hydrogenation;

upstream raw materials:

Indole-3-pyruvic acid

3-(indol-3-yl)pyruvic acid methyl ester

indol-3-yl-pyruvic acid ethyl ester

hydroxy-indol-3-ylmethyl-malonic acid

Downstream raw materials:

(S)-2-hydroxy-3-(1H-indol-3-yl)-propionic acid

Toluene-4-sulfonate1-[2-(1H-indol-3-yl)-2-methoxycarbonyl-ethyl]-4-methoxycarbonylmethyl-pyridinium;

Toluene-4-sulfonate3-acetyl-1-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-pyridinium;

Toluene-4-sulfonate3-ethyl-1-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-pyridinium;

Refernces

• 1、 Fedorov,Doronina,Trotsenko. "Cloning and characterization of indolepyruvate decarboxylase from Methylobacterium extorquens AM1". experimental part. p. 1435 - 1443. Retrieved 2011/12/15.