Technology Process of (4S)-4-benzyl-3-((2S)-1-hydroxy-2-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)but-3-en-1-yl)-5,5-dimethyloxazolidin-2-one
There total 3 articles about (4S)-4-benzyl-3-((2S)-1-hydroxy-2-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)but-3-en-1-yl)-5,5-dimethyloxazolidin-2-one which
guide to synthetic route it.
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synthetic route:
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1449117-84-3
(S)-4-benzyl-5,5-dimethyl-3-((S)-2-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)but-3-enoyl)oxazolidin-2-one
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1449117-85-4
(4S)-4-benzyl-3-((2S)-1-hydroxy-2-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)but-3-en-1-yl)-5,5-dimethyloxazolidin-2-one
- Guidance literature:
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With
diisobutylaluminium hydride;
In
hexane; dichloromethane;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
DOI:10.1021/ol4019562
DOI:10.1021/ol500159h
DOI:10.1021/ol502316x
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1449117-85-4
(4S)-4-benzyl-3-((2S)-1-hydroxy-2-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)but-3-en-1-yl)-5,5-dimethyloxazolidin-2-one
- Guidance literature:
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Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 1 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 - 0 °C / Inert atmosphere
2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.33 h / -78 °C / Inert atmosphere
With
2,6-dimethylpyridine; titanium tetrachloride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
In
hexane; dichloromethane;
1.2: |Evans Aldol Reaction;
DOI:10.1021/ol4019562
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1449117-85-4
(4S)-4-benzyl-3-((2S)-1-hydroxy-2-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)but-3-en-1-yl)-5,5-dimethyloxazolidin-2-one
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 1 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 - 0 °C / Inert atmosphere
2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.33 h / -78 °C / Inert atmosphere
With
2,6-dimethylpyridine; titanium tetrachloride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
In
hexane; dichloromethane;
1.2: |Evans Aldol Reaction;
DOI:10.1021/ol4019562