N,N-Bis(2-chloroethyl)-2-propene-1-amine

Base Information

• Chemical Name: N,N-Bis(2-chloroethyl)-2-propene-1-amine
• CAS No.: 63905-36-2
• Molecular Formula: C7H13 Cl2 N
• Molecular Weight: 182.09
• Hs Code.: 2921199090
• Mol file: 63905-36-2.mol

Synonyms:Diethylamine,2,2'-dichloro-N'-allyl;TL 341;

Chemical Property of N,N-Bis(2-chloroethyl)-2-propene-1-amine

Chemical Property:

• Vapor Pressure: 2.87mmHg at 25°C
• Boiling Point: 156.6°C at 760 mmHg
• PKA: 5.53±0.50(Predicted)
• Flash Point: 48.5°C
• PSA: 3.24000
• Density: 1.076g/cm³
• LogP: 1.95200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Bis(2-chloroethyl)-2-propene-1-amine

There total 2 articles about N,N-Bis(2-chloroethyl)-2-propene-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

2,2′-(prop-2-en-1-ylimino)diethanol (2424-05-7) → N,N-bis(2-chloroethyl)prop-2-en-1-amine (63905-36-2)

Guidance literature:

With thionyl chloride; In chloroform; for 4h; Reflux;

DOI:10.3390/molecules21020171

Reference yield: 58.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + allyl bromide (106-95-6) → N,N-bis(2-chloroethyl)prop-2-en-1-amine (63905-36-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1039/C6RA26104C

Reference yield: 70.0%

N,N-bis(2-chloroethyl)prop-2-en-1-amine (63905-36-2) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 3-allyl-1,5-bis(2-nitrophenoxy)-3-azapentane

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

DOI:10.1080/00397910008086994

upstream raw materials:

2,2′-(prop-2-en-1-ylimino)diethanol

bis-(2-chloroethyl)amine hydrochloride

allyl bromide

Downstream raw materials:

N-allyl-bis(2-aminoethyl)-amine

1-allyl-4-phenyl-piperidine-4-carboxylic acid

1-allyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester

Refernces

• 1、 Toeri, Julius,Laborie, Marie-Pierre,McPhee, Derek J.. "Synthesis and characterization of macrocyclic polyether N,N′-Diallyl-7,16-diaza-1,4,10,13-tetraoxa-dibenzo-18-crown-6". . . Retrieved 2016/04/20.