Levophta

Base Information

• Chemical Name: Levophta
• CAS No.: 79547-78-7
• Molecular Formula: C26H29 F N2 O2 . Cl H
• Molecular Weight: 457.03
• Hs Code.: 2933399090
• European Community (EC) Number: 635-977-8
• Mol file: 79547-78-7.mol

Synonyms:1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-4-piperidinecarboxylic acid;Bilina;lévophta;levocabastine;levocabastine hydrochloride;levophta;livocab;livostin

Chemical Property of Levophta

Chemical Property:

• Vapor Pressure: 8.77E-16mmHg at 25°C
• Boiling Point: 611oC at 760 mmHg
• Flash Point: 323.3oC
• PSA: 64.33000
• LogP: 5.63398
• Storage Temp.: 2-8°C
• Solubility.: DMSO: ~10 mg/mL, soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 456.1979841
• Heavy Atom Count: 32
• Complexity: 681

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3S,4R)-CabastineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Moderately toxic by ingestion.
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CN(CCC1(C2=CC=CC=C2)C(=O)O)C3CCC(CC3)(C#N)C4=CC=C(C=C4)F.Cl
• Isomeric SMILES: C[C@H]1CN(CC[C@]1(C2=CC=CC=C2)C(=O)O)C3CCC(CC3)(C#N)C4=CC=C(C=C4)F.Cl
• Recent EU Clinical Trials: A randomised, double-blind, placebo-controlled, 3 way, incomplete block cross over study in subjects with allergic rhinitis to assess the effect of once daily single and repeat doses of intranasal Fluticasone furoate/Levocabastine fixed dose combination (FDC) relative to Levocabastine and Fluticasone furoate alone on the onset and magnitude of symptoms of rhinitis in an allergen challenge chamber
• Description: Levocabastine hydrochloride is a new, highly potent and specific histamine HI-receptor antagonist without anticholinergic or antiserotonergic side effects. It is reported to have both a fast onset and long duration of action. Indications are the treatment of allergic conjunctivitis and allergic rhinitis.
• Uses: A histamine H1 receptor antagonist used in allergic conjunctivitis.
• Therapeutic Function: Antihistaminic