2-Amino-3-methylbutanenitrile

Base Information

• Chemical Name: 2-Amino-3-methylbutanenitrile
• CAS No.: 4475-96-1
• Molecular Formula: C5H10 N2
• Molecular Weight: 98.1478
• European Community (EC) Number: 889-831-5
• Nikkaji Number: J27.750I
• Mol file: 4475-96-1.mol

Synonyms:2-AMINO-3-METHYLBUTANENITRILE;4475-96-1;2-amino-3-methylbutyronitrile;valinonitrile;2-amino-3-methyl-butyronitrile;a-aminoisovaleronitrile;ZMMPZEFSSVTIIW-UHFFFAOYSA-N;AKOS009128751;CS-0273634;EN300-81019

Chemical Property of 2-Amino-3-methylbutanenitrile

Chemical Property:

• PSA: 49.81000
• LogP: 1.19358
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 98.084398327
• Heavy Atom Count: 7
• Complexity: 87.5

Purity/Quality:

99%min ^*data from raw suppliers

2-AMINO-3-METHYLBUTYRONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C#N)N

Technology Process of 2-Amino-3-methylbutanenitrile

There total 1 articles about 2-Amino-3-methylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium cyanide (143-33-9,25596-52-5) + N-(1-aminoisobutyl)acetamide hydrochloride (91862-00-9) → acetamide (60-35-5) + 2-amino-3-methylbutyronitrile (4475-96-1)

Guidance literature:

With phosphate buffer; at 80 - 85 ℃; Product distribution; influence of pH;

DOI:10.1021/ja00405a036

Reference yield: 79.2%

Lawessons reagent (19172-47-5,94367-93-8) + 2-amino-3-methylbutyronitrile (4475-96-1) → 5-isopropyl-2-(4-methoxy-phenyl)-2-thioxo-2λ5-[1,3,2]diazaphospholidine-4-thione

Guidance literature:

In toluene; for 5h; Heating;

DOI:10.1055/s-2001-18708

Reference yield: 74.0%

2-amino-3-methylbutyronitrile (4475-96-1) → valinamide (13474-14-1,20108-78-5)

Guidance literature:

With formaldehyd; sodium hydroxide; In water; at 20 ℃;

DOI:10.1039/c6cc07530d

upstream raw materials:

sodium cyanide

N-(1-aminoisobutyl)acetamide hydrochloride

Downstream raw materials:

2-amino-3-methylbutanamide hydrochloride

valinamide

D,L-valine

D-Val-OH

Refernces