Technology Process of t-Butyl 3-[4-chloro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-5,6-dimethoxypyrrolo[3,2-b]pyridine-1-carboxylate
There total 9 articles about t-Butyl 3-[4-chloro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-5,6-dimethoxypyrrolo[3,2-b]pyridine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water; toluene
2.1: n-butyllithium; tributyltin chloride / tetrahydrofuran / -75 °C
2.2: Reflux
With
n-butyllithium; tributyltin chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide;
In
tetrahydrofuran; water; toluene;
2.2: Stille coupling;
DOI:10.1111/j.1747-0285.2010.00991.x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: silica gel; iron; acetic acid / toluene / Reflux
2.1: bromine / N,N-dimethyl-formamide / -15 °C
3.1: dmap; triethylamine / N,N-dimethyl-formamide
4.1: n-butyllithium; tributyltin chloride / tetrahydrofuran / -75 °C
4.2: Reflux
With
dmap; n-butyllithium; tributyltin chloride; bromine; silica gel; iron; acetic acid; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
4.2: Stille coupling;
DOI:10.1111/j.1747-0285.2010.00991.x
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: copper(II) nitrate trihydrate; acetic anhydride
2.1: sodium acetate; acetic anhydride / Reflux
3.1: silica gel; iron; acetic acid / toluene / Reflux
4.1: bromine / N,N-dimethyl-formamide / -15 °C
5.1: dmap; triethylamine / N,N-dimethyl-formamide
6.1: n-butyllithium; tributyltin chloride / tetrahydrofuran / -75 °C
6.2: Reflux
With
dmap; n-butyllithium; copper(II) nitrate trihydrate; tributyltin chloride; bromine; sodium acetate; acetic anhydride; silica gel; iron; acetic acid; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
1.2: Henry reaction / 6.2: Stille coupling;
DOI:10.1111/j.1747-0285.2010.00991.x