1-carbethoxy-4-cyano-4-phenyl piperidine

Base Information

• Chemical Name: 1-carbethoxy-4-cyano-4-phenyl piperidine
• CAS No.: 37971-68-9
• Molecular Formula: C₁₅H₁₈N₂O₂
• Molecular Weight: 258.32
• Mol file: 37971-68-9.mol

Synonyms:1-carbethoxy-4-cyano-4-phenyl piperidine

Chemical Property of 1-carbethoxy-4-cyano-4-phenyl piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-carbethoxy-4-cyano-4-phenyl piperidine

There total 3 articles about 1-carbethoxy-4-cyano-4-phenyl piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

phenylacetonitrile (140-29-4) + 2-bromo-N(2-bromoethyl)-N-carbethoxy-ethanamine (77697-11-1) → 1-carbethoxy-4-cyano-4-phenyl piperidine (37971-68-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 12h;

Reference yield:

bis(2-bromoethyl)amine hydrobromide (43204-63-3) → 1-carbethoxy-4-cyano-4-phenyl piperidine (37971-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / aq. NaOH

2: 78 percent / NaH / dimethylformamide / 12 h / 50 °C

With sodium hydroxide; sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

→ 1-carbethoxy-4-cyano-4-phenyl piperidine (37971-68-9)

Guidance literature:

Bis(β-chlorethyl)carbaminsaeureethylester, NaNH2, Benzylcyanid;

DOI:10.1002/jps.2600610833

upstream raw materials:

phenylacetonitrile

2-bromo-N(2-bromoethyl)-N-carbethoxy-ethanamine

bis(2-bromoethyl)amine hydrobromide

Refernces