tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

Base Information

• Chemical Name: tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate
• CAS No.: 546141-51-9
• Molecular Formula: C₂₆H₃₂ClNO₄
• Molecular Weight: 457.997
• Mol file: 546141-51-9.mol

Synonyms:tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

Chemical Property of tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate

There total 1 articles about tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-chloro-5-iodopentane (60274-60-4) + tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate (112741-49-8,173397-90-5) → tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate (546141-51-9)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 2.5h;

DOI:10.1021/jm020482k

Reference yield: 87.0%

tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate (546141-51-9) → (3S,5S,6R)-3-(5-Chloro-pentyl)-5,6-diphenyl-morpholin-2-one (546141-52-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 4h;

DOI:10.1021/jm020482k

Reference yield:

trifluoroacetic acid (76-05-1) + tert-butyl (3S,5S,6R)-3-(5-chloropentyl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate (546141-51-9) → (3S,5S,6R)-3-(5-chloro-pentyl)-5,6-diphenyl-morpholin-2-one trifluoroacetate

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

1-chloro-5-iodopentane

tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate

Downstream raw materials:

(3S,5S,6R)-3-(5-Chloro-pentyl)-5,6-diphenyl-morpholin-2-one

(S)-perhydro-2-azepinecarboxylic acid

(2S)-1-(tert-butoxycarbonyl)-2-azepanecarboxylic acid

benzyl L-azepanyl-D-lactate

Refernces

• 1、 Dutton, Fred E.,Lee, Byung H.,Johnson, Sandra S.,Coscarelli, Eileen M.,Lee, Pil H.. "Restricted conformation analogues of an anthelmintic cyclodepsipeptide". . p. 2057 - 2073. Retrieved 2007/10/03.