Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 1.5 h / 0 °C
1.2: 19 h / 20 °C / Cooling with ice
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere
2.2: 1.5 h / 20 °C
3.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C
4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,2-dimethoxyethane / 0.33 h / 120 °C / microwave irradiation
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C
6.1: triethylamine / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
7.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / microwave irradiation
8.1: hydrogenchloride / 1,4-dioxane; ethanol / 5 h / 75 °C
With
hydrogenchloride; sodium hypochlorite; N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium hydride; sodium hydrogencarbonate; sodium carbonate; triethylamine; sodium bromide;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;