Chemical Property of Colestilan
Edit
Chemical Property:
- Vapor Pressure:0.0138mmHg at 25°C
- Boiling Point:267 °C at 760 mmHg
- Flash Point:144.9 °C
- PSA：29.04000
- Density:g/cm3
- LogP:-3.31200
- Storage Temp.:Room Temperature
- Solubility.:Insoluble in All solvent tried
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:1
- Exact Mass:174.0559907
- Heavy Atom Count:11
- Complexity:82.7
- Purity/Quality:
-
98%,99%, *data from raw suppliers
Colestilan *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=NC=CN1.C1C(O1)CCl
- Recent ClinicalTrials:Drug-Drug Interaction Study to Evaluate the Effect of Colestilan on the Pharmacokinetics of Single Doses of Candesartan Cilexetil in Healthy Subjects
- Recent EU Clinical Trials:A Multi-centre, Flexible Dose, Parallel Group, Open-label, Active Control (Calcium-based Phosphate Binder), Long-term Extension Study Evaluating the Efficacy, Safety and Tolerability of Colestilan (MCI-196) in Paediatric Subjects With Hyperphosphataemia and With Either Chronic Kidney Disease Stage 5 on Dialysis or Chronic Kidney Disease Stages 3b to 5 Not on Dialysis
- Recent NIPH Clinical Trials:Comparison of colestimide /elovixibat combination therapy versus colestimide /placebo combintion in NASH patients with dyslipidemia: a multicenter, double-blind, randomized controlled study(NECST)
-
Description
Colestimide
was launched in Japan for the treatment of hyperlipidemia
and hypercholesterolemia. It is a newly developed methyl imidazoleepichlorhydrin
copolymer; this anion exchange resin works as a powerful bile
acid sequestrant, thus increasing the rate of conversion of cholesterol to bile
acids in the liver which may lead to enhancement of the rate of LDL removal. In
animal models and humans, Colestimide proved to be more potent than
cholestyramine and seems to be better tolerated. It reduced plasma levels of
total and LDL cholesterol and did not alter HDL and triglyceride levels.
Colestimide can be used in monotherapy or co-administered with HMG-CoA
reductase inhibitors.
-
Uses
Colestilan, is a copolymer of 2-methyl-1H-imidazole and epichlorohydrin, and a bile acid sequestrans, that can be used for the treatment of hypercholesterolemia and dyslipidemia.
