Isophosphinoline

Base Information

• Chemical Name: Isophosphinoline
• CAS No.: 253-37-2
• Molecular Formula: C₉H₇P
• Molecular Weight: 146.128
• Mol file: 253-37-2.mol

Synonyms:2-Phosphanaphthalene

Chemical Property of Isophosphinoline

Chemical Property:

• PSA: 34.14000
• LogP: 2.76740

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isophosphinoline

There total 4 articles about Isophosphinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dihydro-isophosphinoline (57328-57-1) → 2-Phosphanaphthalin (253-37-2)

Guidance literature:

Multistep reaction; (i) COCl₂, toluene, (ii) Et₃N;

DOI:10.1016/0040-4020(75)80131-1

Reference yield:

2-oxo-1,2-dihydro-2λ5-isophosphinolin-2-ol (57328-54-8) → 2-Phosphanaphthalin (253-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) SOCl₂, CHCl₃, (ii) LiAlH₄, THF, Et₂O

2: (i) COCl₂, toluene, (ii) Et₃N

DOI:10.1016/0040-4020(75)80131-1

Reference yield:

2-hydroxy-2-oxo-2,3-dihydro-1H-2λ5-isophosphinolin-4-one (4762-76-9) → 2-Phosphanaphthalin (253-37-2)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) NaBH₄, aq. NaOH, (ii) aq. H₂SO₄

2: (i) SOCl₂, CHCl₃, (ii) LiAlH₄, THF, Et₂O

3: (i) COCl₂, toluene, (ii) Et₃N

DOI:10.1016/0040-4020(75)80131-1

upstream raw materials:

1,2-dihydro-isophosphinoline

2-oxo-1,2-dihydro-2λ⁵-isophosphinolin-2-ol

2-hydroxy-2-oxo-2,3-dihydro-1H-2λ⁵-isophosphinolin-4-one