ThiaMine IMpurity C

Base Information

• Chemical Name: ThiaMine IMpurity C
• CAS No.: 7275-24-3
• Molecular Formula: C₁₂H₁₆ClN₄S*ClH*Cl
• Molecular Weight: 355.719
• Mol file: 7275-24-3.mol

Synonyms:Beclotiamine Hydrochloride;3-(4-Amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-chlor-aethyl)-4-methyl-thiazolium, Chlorid-hydrochlorid;

Chemical Property of ThiaMine IMpurity C

Chemical Property:

• Melting Point: >190°C (dec.)
• PSA: 83.92000
• LogP: 0.24140
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99%, ^*data from raw suppliers

BeclotiamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ThiaMine IMpurity C

There total 16 articles about ThiaMine IMpurity C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-amino-2-methyl-pyrimidin-5-yl)-acetic acid ethyl ester (220895-93-2) → 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-chloro-ethyl)-4-methyl-thiazolium; chloride-hydrochloride (7275-24-3)

Guidance literature:

Multi-step reaction with 5 steps

1: N₂H₄+H₂O

2: KNO₂; water; HCl

4: toluene; P₂S₅

With hydrogenchloride; potassium nitrite; tetraphosphorus decasulfide; water; hydrazine hydrate; toluene;

Reference yield:

(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid ethyl ester (14273-42-8) → 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-chloro-ethyl)-4-methyl-thiazolium; chloride-hydrochloride (7275-24-3)

Guidance literature:

Multi-step reaction with 6 steps

1: POCl₃ / folgendes Erhitzen mit aethanol.NH₃

2: N₂H₄+H₂O

3: KNO₂; water; HCl

5: toluene; P₂S₅

With hydrogenchloride; potassium nitrite; tetraphosphorus decasulfide; water; hydrazine hydrate; toluene; trichlorophosphate;

Reference yield:

(2-methyl-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-5-yl)-acetic acid ethyl ester → 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-chloro-ethyl)-4-methyl-thiazolium; chloride-hydrochloride (7275-24-3)

Guidance literature:

Multi-step reaction with 8 steps

1: POCl₃

2: NH₃

3: zinc; aqueous acetic acid

4: N₂H₄+H₂O

5: KNO₂; water; HCl

7: toluene; P₂S₅

With hydrogenchloride; potassium nitrite; tetraphosphorus decasulfide; ammonia; water; hydrazine hydrate; acetic acid; toluene; zinc; trichlorophosphate;

upstream raw materials:

4-Amino-2-methyl-5-thioformamidomethylpyrimidin

3, 5-dichloro-2-pentanone

(4-amino-2-methyl-pyrimidin-5-yl)-acetic acid hydrazide

5-(aminomethyl)-2-methylpyrimidin-4-amine