(±)-2,2,2-trifluoro-1-phenylethyl acetate

Base Information

• Chemical Name: (±)-2,2,2-trifluoro-1-phenylethyl acetate
• CAS No.: 84194-69-4
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.175
• Mol file: 84194-69-4.mol

Synonyms:(±)-2,2,2-trifluoro-1-phenylethyl acetate

Chemical Property of (±)-2,2,2-trifluoro-1-phenylethyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (±)-2,2,2-trifluoro-1-phenylethyl acetate

There total 8 articles about (±)-2,2,2-trifluoro-1-phenylethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-phenyl-2,2,2-trifluoromethylethanol (340-04-5,340-05-6) + acetic anhydride (108-24-7) → (±)-2,2,2-trifluoro-1-phenylethyl acetate (84194-69-4)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1016/j.jfluchem.2013.06.014

Reference yield:

carbon monoxide (201230-82-2) → 1-phenyl-2,2,2-trifluoromethylethanol (340-04-5,340-05-6) + (±)-2,2,2-trifluoro-1-phenylethyl acetate (84194-69-4)

Guidance literature:

In diethyl ether; for 2h; under 760 Torr; Title compound not separated from byproducts; Ambient temperature;

Reference yield:

Isopropenyl acetate (108-22-5) + 1-phenyl-2,2,2-trifluoromethylethanol (340-04-5,340-05-6) → (±)-2,2,2-trifluoro-1-phenylethyl acetate (84194-69-4) + S(+)-1-phenyl-2,2,2-trifluoroethanol (340-06-7)

Guidance literature:

With lipase from Pseudomonas cepacia immobilized on ceramic; In toluene; at 40 ℃; for 15h;

DOI:10.1007/s00706-003-0025-1

upstream raw materials:

acetic acid

2,2,2-trifluoro-1-phenylethyl trifluoromethanesulfonate

S-phenyl thioacetate

4-cyanophenyl acetate

Downstream raw materials:

(R)-2,2,2-trifluoro-1-phenylethanol

S(+)-1-phenyl-2,2,2-trifluoroethanol

1-phenyl-2,2,2-trifluoromethylethanol

Refernces

• 1、 Ghanem, Ashraf,Schurig, Volker. "Lipase-catalyzed Irreversible Transesterification of Secondary Alcohols Using Isopropenyl Acetate". . p. 1151 - 1157. Retrieved 2007/10/03.
• 2、 Kim, Yong-Joo,Osakada, Kohtaro,Takenaka, Akio,Yamamoto, Akio. "Alkylnickel and -palladium alkoxides associated with alcohols through hydrogen bonding". . p. 1096 - 1104. Retrieved 2007/10/02.