Busulfan

Base Information Edit

Chemical Name:Busulfan
CAS No.:55-98-1
Molecular Formula:C6H14O6S2
Molecular Weight:246.306
Hs Code.:29053990
European Community (EC) Number:200-250-2
NSC Number:755916,750
UN Number:2811
UNII:G1LN9045DK
DSSTox Substance ID:DTXSID3020910
Nikkaji Number:J2.316G
Wikipedia:Busulfan
Wikidata:Q348922
NCI Thesaurus Code:C321
RXCUI:1828
Metabolomics Workbench ID:43254
ChEMBL ID:CHEMBL820
Mol file:55-98-1.mol

Synonyms:Busulfan;Busulfan Wellcome;Busulfex;Busulphan;Glyzophrol;Myelosan;Myléran;Mylecytan;Myleran;n-Butane-1,3-di(methylsulfonate);Wellcome, Busulfan

Suppliers and Price of Busulfan

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Busulfan
25g
$ 70.00

TCI Chemical
1,4-Butanediol Dimethanesulfonate >97.0%(T)
25g
$ 65.00

Sigma-Aldrich
Busulfan analytical standard, for drug analysis
25g
$ 66.30

Sigma-Aldrich
Busulfan analytical standard, for drug analysis
10g
$ 32.70

Sigma-Aldrich
Busulfan British Pharmacopoeia (BP) Reference Standard
$ 226.00

Sigma-Aldrich
Busulfan British Pharmacopoeia (BP) Reference Standard
bp403
$ 226.00

Sigma-Aldrich
Busulfan solution
058-1ml
$ 202.00

Sigma-Aldrich
Busulfan European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Busulfan European Pharmacopoeia (EP) Reference Standard
b1170000
$ 190.00

DC Chemicals
Busulfan/Myleran >98%
1 g
$ 300.00

Total 137 raw suppliers

Chemical Property of Busulfan Edit

Chemical Property:

Appearance/Colour:white crystalline solid
Melting Point:114-118 °C
Refractive Index:1.5630 (estimate)
Boiling Point:464 °C at 760 mmHg
Flash Point:234.4 °C
PSA：103.50000
Density:1.35 g/cm³
LogP:1.88060
Storage Temp.:Hygroscopic, Refrigerator, Under Inert Atmosphere
Solubility.:Very slightly soluble in water, freely soluble in acetone and in acetonitrile, very slightly soluble in ethanol (96 per cent).
Water Solubility.:Decomposes
XLogP3:-0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:246.02318051
Heavy Atom Count:14
Complexity:294
Transport DOT Label:Poison

Purity/Quality:

98%,99%, ^*data from raw suppliers

Busulfan ^*data from reagent suppliers

Safty Information:

Pictogram(s): T+,T
Hazard Codes:T+,T,F
Statements: 45-26/27/28-63-46-36/37/38-23/24/25-39/23/24/25-11
Safety Statements: 53-36/37/39-45-28A-36/37-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Antineoplastic Agents, Alkylating Agents
Canonical SMILES:CS(=O)(=O)OCCCCOS(=O)(=O)C
Recent ClinicalTrials:Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 Deficiency
Recent EU Clinical Trials:A Phase 3 Study to Evaluate the Safety and Efficacy of a Single Dose of CTX001 in Pediatric Subjects With Transfusion-Dependent ?-Thalassemia
Recent NIPH Clinical Trials:Clinical trial for neuroblastoma patients with additional chemotherapy and KIR ligand mismatched allogeneic cord blood transplantation
Description Chemically, busulfan is classified as an alkyl sulfonate. One or both of the methylsulfonate ester moieties can be displaced by the nucleophilic N7 of guanine, leading to monoalkylated and cross-linked DNA. The extent of alkyl sulfonate–mediated DNA interstrand cross-linking has been shown to vary with the length of the alkyl chain between sulfonate esters, with the tetramethylene-containing busulfan showing less interstrand cross-linking capability than hexamethylene, methylene, or octamethylene analogues. Intrastrand cross-linking also occurs, preferentially at 5′-GA-3′ but also at 5′-GG-3′ sequences. Alkylation of Cys sulfhydryl groups is yet another mechanism of cytotoxicity.
Uses Antineoplastic alkylating agent, the palliative treatment of chronic myeloid leukemia, and insect sterilant. Busulfan USP (Myleran) is used to treat Chronic granulocytic leukemia; other myeloproliferative disorders.
Indications Busulfan (Myleran) is a bifunctional methanesulfonic ester that forms intrastrand cross-linkages with DNA. The drug is well absorbed after oral administration and has a plasma half-life of less than 5 minutes. Metabolites and degradation products are excreted primarily in the urine. Busulfan is used in the palliative treatment of chronic granulocytic leukemia. Daily oral therapy results in decreased peripheral white blood cells and improved symptoms in almost all patients during the chronic phase of the disease. Excessive uric acid production from rapid tumor cell lysis should be prevented by coadministration of allopurinol. At usual therapeutic dosages, busulfan is selectively toxic to granulocyte precursors rather than lymphocytes. Thrombocytopenia and anemia and less commonly, nausea, alopecia, mucositis, and sterility also may occur. Unusual side effects of busulfan include gynecomastia, a general increase in skin pigmentation, and interstitial pulmonary fibrosis.
Therapeutic Function Antineoplastic
Clinical Use Busulfan is used in the treatment of chronic myelogenous leukemia and can be administered either orally or by IV infusion.
Drug interactions Potentially hazardous interactions with other drugs Antibacterials: concentration increased by metronidazole. Antipsychotics: avoid with clozapine, increased risk of agranulocytosis. Antifungals: metabolism inhibited by itraconazole, monitor for signs of busulfan toxicity.

Technology Process of Busulfan

There total 8 articles about Busulfan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%