Technology Process of (E)-α-(3,4,5-trimethoxybenzylidene)-β-(3,4,5-trimethoxybenzyl)-γ-butyrolactone
There total 8 articles about (E)-α-(3,4,5-trimethoxybenzylidene)-β-(3,4,5-trimethoxybenzyl)-γ-butyrolactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: t-BuOH / 2-methyl-propan-2-ol / 0.5 h / 40 °C
2: H2 / 10percent Pd/C / methanol / 6 h / 760 Torr
3: 1.) t-BuOK, 2.) NaBH4, CaCl2 / 1.) EtOH, 2.) EtOH, RT, 12 h
4: 1.) LDA / 1.) hexane, THF, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 1 h
5: Et3N, 4-(dimethylamino)pyridine / tetrahydrofuran / 5 h / Ambient temperature
6: NaH / tetrahydrofuran / 12 h / Ambient temperature
With
dmap; sodium tetrahydroborate; potassium tert-butylate; hydrogen; sodium hydride; triethylamine; calcium chloride; tert-butyl alcohol; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; tert-butyl alcohol;
DOI:10.1246/bcsj.69.2281
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2 / 10percent Pd/C / methanol / 6 h / 760 Torr
2: 1.) t-BuOK, 2.) NaBH4, CaCl2 / 1.) EtOH, 2.) EtOH, RT, 12 h
3: 1.) LDA / 1.) hexane, THF, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 1 h
4: Et3N, 4-(dimethylamino)pyridine / tetrahydrofuran / 5 h / Ambient temperature
5: NaH / tetrahydrofuran / 12 h / Ambient temperature
With
dmap; sodium tetrahydroborate; potassium tert-butylate; hydrogen; sodium hydride; triethylamine; calcium chloride; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;
DOI:10.1246/bcsj.69.2281
