8-azido-O-trityloctahydroxamate

Base Information

• Chemical Name: 8-azido-O-trityloctahydroxamate
• CAS No.: 1208863-20-0
• Molecular Formula: C₂₇H₃₀N₄O₂
• Molecular Weight: 442.561
• Mol file: 1208863-20-0.mol

Synonyms:8-azido-O-trityloctahydroxamate

Chemical Property of 8-azido-O-trityloctahydroxamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-azido-O-trityloctahydroxamate

There total 2 articles about 8-azido-O-trityloctahydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

O-tritylhydroxylamine (31938-11-1) + 8-azido octanoic acid (217180-76-2) → 8-azido-O-trityloctahydroxamate (1208863-20-0)

Guidance literature:

8-azido octanoic acid; With 4-methyl-morpholine; In tetrahydrofuran; at -15 ℃;

With isobutyl chloroformate; In tetrahydrofuran; at -15 ℃;

O-tritylhydroxylamine; With 4-methyl-morpholine; In tetrahydrofuran; at -15 - 20 ℃;

DOI:10.1016/j.bmc.2009.10.042

Reference yield: 88.0%

→ 8-azido-O-trityloctahydroxamate (1208863-20-0)

Guidance literature:

Reference yield: 88.5%

8-azido-O-trityloctahydroxamate (1208863-20-0) + 3-Biphenylylacetylene (58650-11-6) → C41H40N4O2 (1208863-08-4)

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2009.10.042

upstream raw materials:

O-tritylhydroxylamine

8-azido octanoic acid

Downstream raw materials:

C₃₄H₃₅N₅O₂

C₄₀H₄₀N₄O₃

C₃₅H₃₆N₄O₂

C₃₇H₄₁N₅O₂

Refernces

• 1、 Patil, Vishal,Guerrant, William,Chen, Po C.,Gryder, Berkley,Benicewicz, Derek B.,Khan, Shabana I.,Tekwani, Babu L.,Oyelere, Adegboyega K.. "Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group". experimental part. p. 415 - 425. Retrieved 2010/03/30.