Technology Process of N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-ethynyl-2-phenyl-pyrimidin-4-amine
There total 8 articles about N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-ethynyl-2-phenyl-pyrimidin-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; sodium hydroxide;
In
methanol;
at 20 ℃;
for 0.25h;
pH=12;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid; N-iodo-succinimide / 1 h / 50 °C
2.1: phosphorus(V) oxybromide / 8 h / 100 °C
3.1: butan-1-ol / 24 h / 90 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C
4.2: 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
6.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C
7.1: sodium hydroxide; water / methanol / 0.25 h / 20 °C / pH 12
With
N-iodo-succinimide; water; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; phosphorus(V) oxybromide;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
In
tetrahydrofuran; methanol; dichloromethane; mineral oil; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: phosphorus(V) oxybromide / 8 h / 100 °C
2.1: butan-1-ol / 24 h / 90 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C
3.2: 2 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C
6.1: sodium hydroxide; water / methanol / 0.25 h / 20 °C / pH 12
With
water; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; phosphorus(V) oxybromide;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
In
tetrahydrofuran; methanol; dichloromethane; mineral oil; butan-1-ol;