3-Fluoro-4,6-dinitrophenol

Base Information

• Chemical Name: 3-Fluoro-4,6-dinitrophenol
• CAS No.: 367-82-8
• Molecular Formula: C₆H₃FN₂O₅
• Molecular Weight: 202.099
• Mol file: 367-82-8.mol

Synonyms:3-Fluoro-4,6-dinitrophenol

Chemical Property of 3-Fluoro-4,6-dinitrophenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Fluoro-4,6-dinitrophenol

There total 10 articles about 3-Fluoro-4,6-dinitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,5-difluoro-2,4-dinitrobenzene (327-92-4) → 3-Fluoro-4,6-dinitrophenol (367-82-8)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 20 ℃; Reagent/catalyst; Cooling with ice;

Reference yield: 3.4%

(2,4-difluorophenyl)trimethylsilane (148854-10-8) → 1,5-difluoro-2,4-dinitrobenzene (327-92-4) + 2,4-Difluoronitrobenzene (446-35-5) + 3-Fluoro-4,6-dinitrophenol (367-82-8) + 2,4-Difluoro-5-nitrophenyltrimethylsilane

Guidance literature:

With water; nitric acid; acetic anhydride; In acetic acid; at 50 ℃; for 69h;

DOI:10.1016/S0022-1139(98)00253-X

Reference yield: 2.3%

(2,4-difluorophenyl)trimethylsilane (148854-10-8) → 1,3-Difluorobenzene (372-18-9) + 2,4-Difluoronitrobenzene (446-35-5) + 3-Fluoro-4,6-dinitrophenol (367-82-8)

Guidance literature:

With water; nitric acid; acetic anhydride; at 45 ℃; for 22h;

DOI:10.1016/S0022-1139(98)00253-X

upstream raw materials:

5-fluoro-2-nitrophenol

3-fluorophenol

3-fluoro-4-nitrophenol

1,5-difluoro-2,4-dinitrobenzene

Downstream raw materials:

butyl 2,4-dinitro-5-fluorophenoxyacetate

1,3-diamino-4,6-dinitrobenzene

Refernces

• 1、 -. "A 2 - (5 - fluoro - 2, 4 - two-nitrobenzene oxygen) acetate preparation method". Page/Page column 5; 6. . Retrieved 2019/01/08.
• 2、 Broxton, Trevor J.. "Micellar Catalysis of Organic Reactions. 32. SNAr Reactions of 1,5-Difluoro-2,4-dinitrobenzene and Related Compounds in the Presence of Cationic Micelles". . p. 5958 - 5960. Retrieved 2007/10/02.