Technology Process of 1-(3,4-dimethylbenzyl)-N-(4-formylphenyl)-5-methyl-1H-indole-3-carboxamide
There total 5 articles about 1-(3,4-dimethylbenzyl)-N-(4-formylphenyl)-5-methyl-1H-indole-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4-methylmorpholine N-oxide;
tetrapropylammonium perruthennate;
In
acetonitrile;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C
2: triethylamine / dichloromethane / 20 °C
3: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / acetonitrile / 2 h / 20 °C
With
oxalyl dichloride; 4-methylmorpholine N-oxide; triethylamine;
tetrapropylammonium perruthennate; N,N-dimethyl-formamide;
In
dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: caesium carbonate / acetonitrile / 3 h / 50 °C / Reflux
2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 80 °C
2.2: 0 °C
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C
4.1: triethylamine / dichloromethane / 20 °C
5.1: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / acetonitrile / 2 h / 20 °C
With
oxalyl dichloride; water; caesium carbonate; 4-methylmorpholine N-oxide; triethylamine; sodium hydroxide;
tetrapropylammonium perruthennate; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;