1-Formylpiperazine

Base Information

• Chemical Name: 1-Formylpiperazine
• CAS No.: 7755-92-2
• Molecular Formula: C5H10N2O
• Molecular Weight: 114.147
• Hs Code.: 29335990
• European Community (EC) Number: 231-813-0
• NSC Number: 511082
• DSSTox Substance ID: DTXSID1064790
• Nikkaji Number: J254B
• Wikidata: Q27452019
• Mol file: 7755-92-2.mol

Synonyms:1-Formylpiperazine;7755-92-2;1-Piperazinecarboxaldehyde;Piperazine-1-carbaldehyde;1-Piperazinecarbaldehyde;Formylpiperazine;N-Formylpiperazine;Piperazine-1-carboxaldehyde;EINECS 231-813-0;NSC 511082;1-formyl piperazine;l-formylpiperazine;4-formylpiperazine;N-formyl piperazine;N-formyl-piperazine;4-formyl-piperazine;1-Formyl-piperazine;MFCD00005963;NSC511082;piperazinecarboxaldehyde;piperazin-1-yl-methanone;1-Piperazinecarbaldehyde #;SCHEMBL8467;DTXSID1064790;CHEBI:151031;STK802250;AKOS001146173;AM81361;CS-W016606;NSC-511082;AS-15753;1-Formylpiperazine, technical grade, 85%;A9816;F0194;FT-0636589;1-Formylpiperazine, technical, >=90% (GC);EN300-20598;J-504634;piperazine-1-carbaldehyde;Q27452019;F2190-0515;Z104479110;1FP

Chemical Property of 1-Formylpiperazine

Chemical Property:

• Appearance/Colour: clear colorless to faintly yellow liquid
• Vapor Pressure: 0.00192mmHg at 25°C
• Melting Point: 88-91 °C
• Refractive Index: 1.5097 - 1.5117
• Boiling Point: 291.7 °C at 760 mmHg
• PKA: 8.58±0.10(Predicted)
• Flash Point: 101.7 °C
• PSA: 32.34000
• Density: 1.107 g/cm³
• LogP: -0.04940
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 114.079312947
• Heavy Atom Count: 8
• Complexity: 78.5

Purity/Quality:

99% ^*data from raw suppliers

1-Formylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C=O
• Uses: 1-Formylpiperazine is sutable for use as a test compound in the kinetic study of the reaction of 4-nitrophenyl 2-thiophenecarboxylate with secondary alicyclic amines.

Technology Process of 1-Formylpiperazine

There total 18 articles about 1-Formylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

piperazine (110-85-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → piperazine-1-carbaldehyde (7755-92-2)

Guidance literature:

With oxygen; sodium hydroxide; In water; at 24.84 ℃; for 6h; under 760.051 Torr;

DOI:10.1039/c5gc01992c

Reference yield: 76.0%

piperazine (110-85-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → piperazine-1-carbaldehyde (7755-92-2)

Guidance literature:

With benzoic acid methyl ester; at 160 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.5012/bkcs.2010.31.5.1424

Reference yield: 74.0%

piperazine (110-85-0) + carbon dioxide (124-38-9,18923-20-1) → piperazine-1-carbaldehyde (7755-92-2)

Guidance literature:

With sodium (phenyltrihydroxyborate); phenylsilane; In diethylene glycol dimethyl ether; at 60 ℃; for 12h; under 1875.19 Torr; Sealed tube; Glovebox; Autoclave;

DOI:10.1039/d0gc01741h

upstream raw materials:

piperazine

N,N'-diformylpiperazine

Methyl formate

formamide

Downstream raw materials:

phenol

4-nitro-phenol

4-(4-Methyl-2-nitro-phenyl)-piperazine-1-carbaldehyde

6-nitroquipazine

Refernces

• 1、 -. "A preparation method of Ranolazine". Paragraph 0038; 0041; 0043. . Retrieved 2019/03/28.
• 2、 Wang, Yehong,Zhang, Jian,Chen, Haijun,Zhang, Zhixin,Zhang, Chaofeng,Li, Mingrun,Wang, Feng. "Ru/ceria-catalyzed direct formylation of amines and CO to produce formamides". . p. 88 - 92. Retrieved 2017/01/24.