1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate

Base Information

• Chemical Name: 1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate
• CAS No.: 1159835-40-1
• Molecular Formula: C₂₁H₃₀N₂O₅
• Molecular Weight: 390.48
• Mol file: 1159835-40-1.mol

Synonyms:1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate

Chemical Property of 1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate

There total 5 articles about 1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

C20H28N2O5 + methyl iodide (74-88-4) → 1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate (1159835-40-1)

Guidance literature:

With sodium carbonate; In dimethyl sulfoxide; at 40 ℃; for 2h;

Reference yield: 77.0%

methanol (67-56-1) + 1-(tert-butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid (1159835-31-0) + propionic acid anhydride (123-62-6) → 1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate (1159835-40-1)

Guidance literature:

1-(tert-butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid; propionic acid anhydride; With triethylamine; In ethyl acetate; for 2h; Reflux;

methanol; In ethyl acetate; at 70 ℃; for 3h;

Reference yield:

aniline (62-53-3) → 1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate (1159835-40-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran / 19 h / 0 - 20 °C

2: triethylamine / ethyl acetate / 4 h / 40 °C

3: sodium carbonate / dimethyl sulfoxide / 2 h / 40 °C

With sodium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate;

upstream raw materials:

methanol

1-(tert-butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid

propionic acid anhydride

methyl iodide

Downstream raw materials:

methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate

Refernces

• 1、 -. "FENTANYL HAPTENS, FENTANYL HAPTEN CONJUGATES, AND METHODS FOR MAKING AND USING". Page/Page column 73; 82; 83; 84. . Retrieved 2021/09/17.