1-benzyl-3-(2-fluorobenzyl)-3-pyrrolidinol

Base Information

• Chemical Name: 1-benzyl-3-(2-fluorobenzyl)-3-pyrrolidinol
• CAS No.: 71916-76-2
• Molecular Formula: C₁₈H₂₀FNO
• Molecular Weight: 285.361
• Mol file: 71916-76-2.mol

Synonyms:1-benzyl-3-(2-fluorobenzyl)-3-pyrrolidinol

Chemical Property of 1-benzyl-3-(2-fluorobenzyl)-3-pyrrolidinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzyl-3-(2-fluorobenzyl)-3-pyrrolidinol

There total 1 articles about 1-benzyl-3-(2-fluorobenzyl)-3-pyrrolidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyl-3-pyrrolidinone (775-16-6) + 2-fluorobenzyl chloride (345-35-7) → 1-benzyl-3-(2-fluorobenzyl)-3-pyrrolidinol (71916-76-2)

Guidance literature:

With magnesium; iodine; Yield given. Multistep reaction; 1.) ether, reflux, 20 h; 2.) ether, r.t., 2 h;

Reference yield: 70.0%

1-benzyl-3-(2-fluorobenzyl)-3-pyrrolidinol (71916-76-2) → 1'-benzyl-2,3-dihydrospiro (71916-77-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; benzene; at 90 ℃; for 120h;

Reference yield:

1-benzyl-3-(2-fluorobenzyl)-3-pyrrolidinol (71916-76-2) → 2,3-dihydrospiro (71916-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / 98percent sodium hydride / benzene; dimethylformamide / 120 h / 90 °C

2: 75 percent / H₂ / 10percent palladium on charcoal / propan-2-ol / 50 °C / 2430.6 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In N,N-dimethyl-formamide; isopropyl alcohol; benzene;

upstream raw materials:

N-benzyl-3-pyrrolidinone

2-fluorobenzyl chloride

Downstream raw materials:

1'-benzyl-2,3-dihydrospiro

2,3-dihydrospiro

Refernces

• 1、 -. "Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines". . . Retrieved 2008/06/13.