Fenpropimorph

Base Information

• Chemical Name: Fenpropimorph
• CAS No.: 67564-91-4
• Deprecated CAS: 74545-06-5,74545-07-6,76492-89-2,91269-52-2,95754-31-7,67306-03-0,67306-03-0,74545-07-6,76492-89-2,91269-52-2,95754-31-7
• Molecular Formula: C20H33 N O
• Molecular Weight: 303.488
• Hs Code.: 29349990
• European Community (EC) Number: 266-719-9
• UNII: 4548UM725F
• DSSTox Substance ID: DTXSID4034601,DTXSID901045927
• Nikkaji Number: J310.265C
• Wikipedia: Fenpropimorph
• Wikidata: Q2368524
• Pharos Ligand ID: SF6KPZLY3MN9
• Metabolomics Workbench ID: 57344
• ChEMBL ID: CHEMBL372700
• Mol file: 67564-91-4.mol

Synonyms:4-(3-(4-(1,1-dimethylethyl)phenyl)-2-methylpropyl)-2,6-dimethylmorpholine;fenpropimorph

Chemical Property of Fenpropimorph

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 25°C
• Refractive Index: 1.49
• Boiling Point: 392.7 °C at 760 mmHg
• PKA: 7.34±0.10(Predicted)
• Flash Point: 115.6 °C
• PSA: 12.47000
• Density: 0.928 g/cm³
• LogP: 4.20980
• Water Solubility.: 4.32mg/L at 20℃
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 303.256214676
• Heavy Atom Count: 22
• Complexity: 317

Purity/Quality:

99.9% ^*data from raw suppliers

Fenpropimorph ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn;N,N,Xn
• Statements: 22-38-51/53-63
• Safety Statements: 36/37-46-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CN(CC(O1)C)CC(C)CC2=CC=C(C=C2)C(C)(C)C
• Isomeric SMILES: C[C@@H]1CN(C[C@@H](O1)C)CC(C)CC2=CC=C(C=C2)C(C)(C)C
• Description: Fenpropimorph is a morpholine fungicide. It is colorless, odorless oil. Fenpropimorph, a systemic fungicide, absorbed through the leaves and roots, has protective and curative properties. It can inhibit the sterol pathway. It is mostly used for the control of fungal diseases, including powdery mildew, scald, yellow & brown rusts, and Mycosphaerella. Its is major use is to control diseases in cereals including wheat, barley, oats, rye, and triticale. It could be also applied on bananas, plantains, sugarbeet and beans.
• Uses: Systemic fungicide for control of powdery mildew, rust in cereal crops.

Technology Process of Fenpropimorph

There total 7 articles about Fenpropimorph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

cis-2,6-dimethylmorpholine + lilial (80-54-6) → 3-(p-tert-butylphenyl)-2-methyl-1-propanol (56107-04-1) + fenpropimorph (67564-91-4,91269-52-2,76492-89-2)

Guidance literature:

With hydrogen; at 200 - 240 ℃; for 200 - 3100h; under 37503.8 - 105011 Torr; Product distribution / selectivity;

Reference yield: 81.0%

2,6-dimethyl morpholine (141-91-3) + lilial (80-54-6) → cis-4-<3-(4-tert-butylphenyl)-2-methylpropyl>-2,6-dimethylmorpholine (67564-91-4,91269-52-2,76492-89-2)

Guidance literature:

With formic acid; triethylamine; In water; tert-butyl alcohol; at 100 ℃; for 14h;

DOI:10.1002/cctc.201701617

Reference yield: 0.14%

2-methyl-2-butylchloride (594-36-5) → amorolfine (78613-35-1,288583-04-0,288583-03-9) + cis-4-<3-(4-tert-butylphenyl)-2-methylpropyl>-2,6-dimethylmorpholine (67564-91-4,91269-52-2,76492-89-2)

Guidance literature:

(2R,6S)-2,6-dimethyl-4-(2-methyl-3-phenylpropyl)morpholine hydrochloride; With iron(III) chloride; In dichloromethane;

2-methyl-2-butylchloride; In dichloromethane; at -52 - -20 ℃;

With sodium hydroxide; water; more than 3 stages; Product distribution / selectivity;

upstream raw materials:

lilial

2-methyl-2-butylchloride

(2R,6S)-2,6-dimethyl-4-(2-methyl-3-phenylpropyl)morpholine hydrochloride

2,6-dimethyl morpholine

Refernces

• 1、 -. "PROCESS FOR CONTINUOUS HYDROGENATION OR HYDROGENATING AMINATION". Page/Page column 5. . Retrieved 2010/04/25.
• 2、 -. "Process of producing amorolfine". Page/Page column 8-9. . Retrieved 2008/12/06.