Technology Process of 7-benzyl-4-carboxy-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
There total 7 articles about 7-benzyl-4-carboxy-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-4-carboxylate;
With
methanol; sodium hydroxide; water;
at 85 ℃;
for 1h;
In
water;
pH=~ 4;
Acidic conditions;
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
for 2h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium hydride; acetic acid / methanol / 0.5 h / 20 °C
2: trichlorophosphate / 5 h / Reflux
3: triphenylphosphine; ferrocene; carbon monoxide / ethanol / 100 °C / 7500.75 Torr / Autoclave
4: sodium hydroxide / methanol / 2 h / Reflux
With
ferrocene; carbon monoxide; potassium hydride; acetic acid; triphenylphosphine; sodium hydroxide; trichlorophosphate;
In
methanol; ethanol;