Technology Process of (5S,8S,9R,10S,13S,14S,17S)-9-fluoro-17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,11-dione
There total 11 articles about (5S,8S,9R,10S,13S,14S,17S)-9-fluoro-17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,11-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
1,4-dioxane; methanol;
for 1.5h;
Heating;
DOI:10.1007/BF00763671
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 85.7 percent / (NCOOEt)2, Ph3P / 1.) THF, 4 h, 2.) benzene, 0-5 deg C, 2 h
2: 84 percent / PhICl2 / CH2Cl2 / 0.75 h / 10 - 15 °C / Irradiation
3: 95 percent / 15percent KOH / methanol; dioxane / 1.5 h / Heating
4: 83 percent / benzene; diethyl ether / 1 h / 20 - 25 °C
5: 88 percent / Jones reagent / acetone / 0.33 h / 0 - 5 °C
6: 1.) 10percent aq. HClO4, dibromantin, 2.) 10percent NaOH / 1.) acetone, 20 min, 2.) MeOH, 0-5 deg C, 1.5 h
7: HF, pyridine / 1 h / -78 °C
8: 72 percent / 15percent KOH / methanol; dioxane / 1.5 h / Heating
With
pyridine; potassium hydroxide; sodium hydroxide; perchloric acid; jones reagent; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; (Dichloroiodo)benzene; hydrogen fluoride; triphenylphosphine; diethylazodicarboxylate;
In
1,4-dioxane; methanol; diethyl ether; dichloromethane; acetone; benzene;
DOI:10.1007/BF00763671
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 95 percent / 5percent KOH / methanol / Heating
2: 85.7 percent / (NCOOEt)2, Ph3P / 1.) THF, 4 h, 2.) benzene, 0-5 deg C, 2 h
3: 84 percent / PhICl2 / CH2Cl2 / 0.75 h / 10 - 15 °C / Irradiation
4: 95 percent / 15percent KOH / methanol; dioxane / 1.5 h / Heating
5: 83 percent / benzene; diethyl ether / 1 h / 20 - 25 °C
6: 88 percent / Jones reagent / acetone / 0.33 h / 0 - 5 °C
7: 1.) 10percent aq. HClO4, dibromantin, 2.) 10percent NaOH / 1.) acetone, 20 min, 2.) MeOH, 0-5 deg C, 1.5 h
8: HF, pyridine / 1 h / -78 °C
9: 72 percent / 15percent KOH / methanol; dioxane / 1.5 h / Heating
With
pyridine; potassium hydroxide; sodium hydroxide; perchloric acid; jones reagent; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; (Dichloroiodo)benzene; hydrogen fluoride; triphenylphosphine; diethylazodicarboxylate;
In
1,4-dioxane; methanol; diethyl ether; dichloromethane; acetone; benzene;
DOI:10.1007/BF00763671