Chlormephos

Base Information

• Chemical Name: Chlormephos
• CAS No.: 24934-91-6
• Deprecated CAS: 37209-29-3
• Molecular Formula: C5H12 Cl O2 P S2
• Molecular Weight: 234.708
• Hs Code.: 2930909065
• European Community (EC) Number: 246-538-1
• ICSC Number: 1682
• UN Number: 3018
• UNII: 1N10F47JUS
• DSSTox Substance ID: DTXSID1037511
• Nikkaji Number: J53.800K
• Wikipedia: Chlormephos
• Wikidata: Q421506
• Metabolomics Workbench ID: 55932
• ChEMBL ID: CHEMBL1882960
• Mol file: 24934-91-6.mol

Synonyms:CHLORMEPHOS;Chlormefos;Chlormethylfos;24934-91-6;Dotan;Caswell No. 195B;Chlormephos [BSI:ISO];Phosphorodithioic acid, S-(chloromethyl) O,O-diethyl ester;S-Chloromethyl O,O-diethyl phosphorodithioate;S-(chloromethyl) O,O-diethyl phosphorodithioate;Chlormephos [ISO];MC 2188;CCRIS 1623;HSDB 6456;S-(Chloromethyl) O,O-diethylphosphorodithioate;EINECS 246-538-1;EPA Pesticide Chemical Code 295300;BRN 1680996;UNII-1N10F47JUS;AI3-25533;1N10F47JUS;DTXSID1037511;CHEBI:38603;S-(Chloromethy) O,O-diethyl phosphorodithioate;S-Chloromethyl-O,O-diethylphosphorothiolothionate;chloromethylsulfanyl-diethoxy-sulfanylidene-lambda5-phosphane;S-(Chloromethyl) o,o-diethyl dithiophosphate;4-01-00-03088 (Beilstein Handbook Reference);chloromethylsulfanyl-diethoxy-sulfanylidene-?^{5}-phosphane;CHLORMEPHOS [MI];CHLORMEPHOS [HSDB];C5H12ClO2PS2;SCHEMBL15332;CHEMBL1882960;DTXCID9017511;C5-H12-Cl-O2-P-S2;Tox21_300825;NCGC00163765-01;NCGC00163765-02;NCGC00254729-01;CAS-24934-91-6;Chlormephos 1000 microg/mL in Acetonitrile;LS-108055;O,O-Diethyl S-(Chloromethyl)dithiophosphate;Chlormefos, PESTANAL(R), analytical standard;C18686;P 2188;S-(Chloromethyl) O,O-diethyl dithiophosphate #;Q421506;S-Chloromethyl O,O-diethyl phosphorothiolothionate;J-015737;S-(Chloromethyl) O,O-Diethyl phosphorothiolothionate;S-(Chloromethyl)phosphorodithioic acid O,O-diethyl ester;diethyl [(chloromethyl)sulfanyl](sulfanylidene)phosphonite;Chlormephos, S-(Chloromethyl) O,O-diethyl phosphorodithioate;Methanethiol, chloro-, S-ester with O,O-diethyl phosphorodithioate

Chemical Property of Chlormephos

Chemical Property:

• Vapor Pressure: 0.0362mmHg at 25°C
• Melting Point: 25°C
• Refractive Index: nD220 1.5244
• Boiling Point: 249.5°Cat760mmHg
• Flash Point: 104.7°C
• PSA: 85.66000
• Density: 1.295g/cm³
• LogP: 3.86400
• Storage Temp.: 0-6°C
• Water Solubility.: 60 mg l-1(20 °C)
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 233.9704867
• Heavy Atom Count: 11
• Complexity: 134
• Transport DOT Label: Poison

Purity/Quality:

Chlormefos ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T+,N
• Statements: 27/28-50/53
• Safety Statements: 28-36/37-45-60-61-27

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Organophosphate Insecticides
• Canonical SMILES: CCOP(=S)(OCC)SCCl
• Inhalation Risk: No indication can be given about the rate at which a harmful concentration of this substance in the air is reached.
• Effects of Short Term Exposure: Cholinesterase inhibition. The substance may cause effects on the nervous system. This may result in convulsions and respiratory depression. Exposure could cause death. The effects may be delayed. Medical observation is indicated.
• Effects of Long Term Exposure: Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.
• Uses: Insecticide primarily for soil applications. Chlormephos is used to control soil insects such as wireworms in a number of crops. Chlormefos has agricultural applications. Useful for preparing compositions for controlling plant diseases.

Technology Process of Chlormephos

There total 8 articles about Chlormephos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

dichloromethane (75-09-2) + O,O-Diethyl hydrogen phosphorodithioate (298-06-6) → chlormephos (24934-91-6)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 48 ℃; for 22h; Heating;

Reference yield: 68.0%

dichloromethane (75-09-2) + diethyl dithiophosphate ammonium salt (1068-22-0) → chlormephos (24934-91-6) + Ethion (563-12-2)

Guidance literature:

In N,N-dimethyl-formamide; at 49 ℃; for 22h; Heating;

Reference yield:

O,O-Diethyl hydrogen phosphorodithioate (298-06-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → chlormephos (24934-91-6)

Guidance literature:

With sodium carbonate; In hexane; dichloromethane; water;

upstream raw materials:

chlorobromomethane

potassium O,O-diethyldithiophosphate

dichloromethane

diethyl dithiophosphate ammonium salt

Downstream raw materials:

O,O,S-triethyl phosphorothioate

O,O,S-triethyl phosphorodithioate

O,O,O,O-tetraethyl trithiopyrophosphate

Ethion

Refernces

• 1、 -. "Pesticide compositions and method". . . Retrieved 2008/06/13.
• 2、 Corkins, H. G.,Storace, L.,Weinberger, D.,Osgood, E.,Lowery, S.. "CHLOROMETHYLATION OF O,O-DIETHYL PHOSPHORODITHIOIC ACID USING FORMALDEHYDE AND CHLORINATING REAGENTS". . p. 133 - 138. Retrieved 2007/10/02.