(2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide hydrochloric acid salt

Base Information

• Chemical Name: (2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide hydrochloric acid salt
• CAS No.: 950842-32-7
• Molecular Formula: C₉H₁₈N₂O₂*ClH
• Molecular Weight: 223.707
• Mol file: 950842-32-7.mol

Synonyms:(2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide hydrochloric acid salt

Chemical Property of (2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide hydrochloric acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide hydrochloric acid salt

There total 2 articles about (2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide hydrochloric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide deoxycholic acid salt (950842-31-6) → (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanoic acid amide hydrochloride (944716-73-8,1166397-39-2) + (2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide hydrochloric acid salt (950842-32-7)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 70 - 80 ℃; for 1h;

Reference yield: 75.0%

(2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide deoxycholic acid salt (950842-31-6) → (2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide hydrochloric acid salt (950842-32-7)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 75 ℃; for 1h;

DOI:10.1021/jm901023f

Reference yield:

(2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide hydrochloric acid salt (950842-32-7) + (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid (402958-98-9) → (1S,3aR,6aS)-N-((S)-3-deutero-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Guidance literature:

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 25 ℃;

DOI:10.1021/jm901023f

upstream raw materials:

(2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide deoxycholic acid salt

Refernces

• 1、 -. "Deuterated hepatitis C protease inhibitors". Page/Page column 19; 21. . Retrieved 2010/11/28.