9-[2-Methoxy-4-(methylsulfonylamino)phenylamino]-N,5-dimethyl-4-acridinecarboxamide 2-hydroxyethanesulfonate

Base Information

• Chemical Name: 9-[2-Methoxy-4-(methylsulfonylamino)phenylamino]-N,5-dimethyl-4-acridinecarboxamide 2-hydroxyethanesulfonate
• CAS No.: 80841-48-1
• Molecular Formula: C2H6O4S•C24H24N4O4S
• Molecular Weight: 590.72
• Mol file: 80841-48-1.mol

Synonyms:

Chemical Property of 9-[2-Methoxy-4-(methylsulfonylamino)phenylamino]-N,5-dimethyl-4-acridinecarboxamide 2-hydroxyethanesulfonate

Chemical Property:

• Vapor Pressure: 1.27E-31mmHg at 25°C
• Boiling Point: 861.2°C at 760 mmHg
• Flash Point: 474.6°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-[2-Methoxy-4-(methylsulfonylamino)phenylamino]-N,5-dimethyl-4-acridinecarboxamide 2-hydroxyethanesulfonate

There total 3 articles about 9-[2-Methoxy-4-(methylsulfonylamino)phenylamino]-N,5-dimethyl-4-acridinecarboxamide 2-hydroxyethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-hydroxyethanesulfonic acid (107-36-8) + [14C]-Asulacrine (80841-47-0) → asulacrine isethionate (80841-48-1)

Guidance literature:

In methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; at 5 ℃; for 3.5h;

DOI:10.1002/jhet.5570260542

Reference yield:

5-methyl-9-chloroacridine-4-carbonyl chloride (92138-15-3) → asulacrine isethionate (80841-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂; H₂O

2: concd HCl / methanol / Heating

With hydrogenchloride; In methanol; dichloromethane; water;

DOI:10.1021/jm00369a021

Reference yield:

N-(4-amino-3-methoxyphenyl)methanesulfonamide (57165-06-7) + 9-chloro-4-methyl-5-<(methylamino)carbonyl>acridine (88915-00-8) → asulacrine isethionate (80841-48-1)

Guidance literature:

With hydrogenchloride; In methanol; Heating;

DOI:10.1021/jm00369a021

upstream raw materials:

2-hydroxyethanesulfonic acid

[14C]-Asulacrine

N-(4-amino-3-methoxyphenyl)methanesulfonamide

9-chloro-4-methyl-5-<(methylamino)carbonyl>acridine

Refernces

• 1、 Denny,Atwell,Baguley. "Potential antitumor agents. 40. Orally active 4,5-disubstituted derivatives of amsacrine". . p. 363 - 367. Retrieved 2007/10/02.