C₂₂H₁₈BrF₃N₄O₃

Base Information

• Chemical Name: C₂₂H₁₈BrF₃N₄O₃
• CAS No.: 1429318-81-9
• Molecular Formula: C₂₂H₁₈BrF₃N₄O₃
• Molecular Weight: 523.309
• Mol file: 1429318-81-9.mol

Synonyms:C₂₂H₁₈BrF₃N₄O₃

Chemical Property of C₂₂H₁₈BrF₃N₄O₃

Chemical Property:

Purity/Quality:

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Technology Process of C₂₂H₁₈BrF₃N₄O₃

There total 1 articles about C₂₂H₁₈BrF₃N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

(3-trifluoroacetamido-4-bromophenyl)(mesityl)iodonium hexafluorophosphate + (3S,6S)-3-(3'-indolylmethyl)-6-methylpiperazine-2,5-dione (17079-37-7,19943-35-2,22216-02-0,22216-03-1,22839-21-0,22839-22-1,22839-23-2,26384-48-5) → C22H18BrF3N4O3 (1429318-81-9)

Guidance literature:

(3-trifluoroacetamido-4-bromophenyl)(mesityl)iodonium hexafluorophosphate; (3S,6S)-3-(3'-indolylmethyl)-6-methylpiperazine-2,5-dione; In dichloromethane; at 23 ℃; for 0.166667h;

With C₃₃H₄₈CuF₃N₂O₃S; In dichloromethane; at 23 ℃; for 10h; diastereoselective reaction;

DOI:10.1021/ja4023557

Reference yield: 82.0%

C22H18BrF3N4O3 (1429318-81-9) → C20H19BrN4O2 (1429318-82-0)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 23 ℃; for 1h;

DOI:10.1021/ja4023557

upstream raw materials:

(3S,6S)-3-(3'-indolylmethyl)-6-methylpiperazine-2,5-dione

Downstream raw materials:

C₂₀H₁₉BrN₄O₂

Refernces