1-(4-methoxy)phenyl-3-methyl-5-pyrazolone

Base Information

• Chemical Name: 1-(4-methoxy)phenyl-3-methyl-5-pyrazolone
• CAS No.: 60798-06-3
• Molecular Formula: C11H12 N2 O2
• Molecular Weight: 204.228
• Hs Code.: 2933199090
• Mol file: 60798-06-3.mol

Synonyms:2-Pyrazolin-5-one,1-(p-methoxyphenyl)-3-methyl- (7CI);1-(4-Methoxyphenyl)-3-methyl-4,5-dihydropyrazole-5-one;3-Methyl-1-(4-methoxyphenyl)-2-pyrazolin-5-one

Chemical Property of 1-(4-methoxy)phenyl-3-methyl-5-pyrazolone

Chemical Property:

• Vapor Pressure: 2.28E-06mmHg at 25°C
• Boiling Point: 392.5°C at 760 mmHg
• Flash Point: 191.2°C
• PSA: 41.90000
• Density: 1.19g/cm³
• LogP: 1.30840

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-methoxy)phenyl-3-methyl-5-pyrazolone

There total 19 articles about 1-(4-methoxy)phenyl-3-methyl-5-pyrazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl acetoacetate (141-97-9) + 4-Methoxyphenylhydrazine (3471-32-7) → 1-(4-methoxyphenyl)-3-methyl-2-pyrazolin-5-one (60798-06-3)

Guidance literature:

In acetic acid; Heating;

DOI:10.1002/jhet.5570240128

Reference yield: 97.0%

acetoacetic acid methyl ester (105-45-3) + 4-Methoxyphenylhydrazine (3471-32-7) → 1-(4-methoxyphenyl)-3-methyl-2-pyrazolin-5-one (60798-06-3)

Guidance literature:

With acetic acid; for 3h; Reflux;

DOI:10.1016/j.tetlet.2012.05.148

Reference yield: 85.0%

C11H14N2O2 → 1-(4-methoxyphenyl)-3-methyl-2-pyrazolin-5-one (60798-06-3)

Guidance literature:

With sodium anthraquinone-2-sulfonate; palladium diacetate; potassium carbonate; In chlorobenzene; at 110 ℃; for 6h;

DOI:10.1016/j.tetlet.2019.03.063

upstream raw materials:

4-methoxyphenylhydrazine hydrochloride

ethyl acetoacetate

4-Methoxyphenylhydrazine

5-Methyl-4-(1-methylethylidene)-2-(4'-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one

Downstream raw materials:

5-Methyl-4-(1-methylethylidene)-2-(4'-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one

1-(4-methoxyphenyl)-3-methyl-1H-pyrazol-5-yl trifluoromethanesulfonate

1-(4-methoxyphenyl)-3-methyl-4-(trifluoromethylsulfonyl)-1H-pyrazol-5-ol

5-chloro-1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-4-carbaldehyde

Refernces

• 1、 Khairnar, Pankaj V.,Su, Yin-Hsiang,Edukondalu, Athukuri,Lin, Wenwei. "Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[ c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition". . p. 12326 - 12335. Retrieved 2021/08/24.
• 2、 Yuan, Yong,Li, Liang-Sen,Zhang, Lin,Wang, Feng,Jiang, Lin,Zuo, Lin,Wang, Qi,Hu, Jian-Guo,Lei, Aiwen. "Electrochemical synthesis of versatile ammonium oxides under metal catalyst-, exogenous-oxidant-, and exogenous-electrolyte-free conditions". supporting information. p. 2768 - 2771. Retrieved 2021/03/23.