HUMAN MENOPAUSAL GONADOTROPHIN

Base Information

• Chemical Name: HUMAN MENOPAUSAL GONADOTROPHIN
• CAS No.: 61489-71-2
• Molecular Formula: C9H18O
• Molecular Weight: 142.23862
• Mol file: 61489-71-2.mol

Synonyms:HMG;Human menopausal gonadotrophin;Human menopausal gonadotropin;Humegon;Humegon100;Lepori;Menogon;Menopausal gonadotropin;Menopur;Menotrophin;Menotropin;Merional;Neopergonal;Normegon;Pergonal;Pergonal 150;Pergonal75;Pergovet;Repronex;Urogonadotropin;Menotropins;

Chemical Property of HUMAN MENOPAUSAL GONADOTROPHIN

Chemical Property:

• Appearance/Colour: White or off-white powder
• PSA: 17.07000
• LogP: 2.79180
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): B
• Hazard Codes: B

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Gonad-stimulating principle. Gonadotropin from human menopausal urine has been used as a supplement in pre-incubated maturation medium for the culture of bovine cumulus oocyte complexes (COCs) to study the effects of multiple freeze-thawing of bovine epididymal sperm on in vitro development of embryo.
• Clinical Use: Menotropins are a natural product that is obtained from the urine of postmenopausal women and then biologically standardized (international units [IU]) for FSH and LH activities in an approximate ratio of 1:1. Menotropins are used in males with primary (hypothalamic) or secondary (pituitary) hypogonadism to stimulate spermatogenesis, providing they have been treated previously with human chorionic gonadotropin (hCG; a peptide hormone of placental origin that has activity very similar to LH) to effect masculinization (increased testosterone inducing ovulation in women who are having difficulty ovulating as a result of either hypothalamic or pituitary hormonal dysfunction. The menotropins are given for 7 to 12 days, and after clinical evaluation (via ultrasound) indicates the presence of a mature follicle, a single dose of hCG is given to simulate the typical LH surge that normally triggers ovulation. Also, women use the combination of menotropins and hCG to promote the development of multiple follicles when they are participating in an IVF program requiring the recruitment of follicles.