Technology Process of (2-benzenesulfonyl-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-yl)dimethylamine
There total 10 articles about (2-benzenesulfonyl-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-yl)dimethylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
dimethyl-(2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-yl)amine;
With
n-butyllithium;
In
tetrahydrofuran; hexane; chloroform;
at -70 - -30 ℃;
for 2h;
benzenesulfonyl chloride;
In
tetrahydrofuran; hexane;
at -70 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: trichlorophosphate / 2 h / 20 °C
1.2: 0.25 h
2.1: dmap / acetonitrile / 3 h / 0 °C
3.1: 1,4-diaza-bicyclo[2.2.2]octane / 24 h / 4 °C
4.1: pyridine; acetic anhydride / 1 h / 0 °C
4.2: 6 h / 80 °C
5.1: sodium hydroxide / tetrahydrofuran; water / 1 h
5.2: 3 h / 50 °C
6.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C
6.2: 4 h / 0 °C
7.1: 1,4-dioxane / 0.33 h / Heating / reflux
8.1: hydrogenchloride / 1,4-dioxane; water / 0.33 h / Heating / reflux
9.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 1 h / 20 °C
10.1: n-butyllithium / tetrahydrofuran; hexane; chloroform / 2 h / -70 - -30 °C
10.2: -70 - 20 °C
With
pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; dmap; sodium hydroxide; n-butyllithium; chloroformic acid ethyl ester; acetic anhydride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trichlorophosphate;
In
tetrahydrofuran; 1,4-dioxane; hexane; chloroform; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran / 19 h / 0 °C
2.1: sodium hydroxide / tetrahydrofuran; water / 1 h
2.2: 3 h / 50 °C
3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C
3.2: 4 h / 0 °C
4.1: 1,4-dioxane / 0.33 h / Heating / reflux
5.1: hydrogenchloride / 1,4-dioxane; water / 0.33 h / Heating / reflux
6.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 1 h / 20 °C
7.1: n-butyllithium / tetrahydrofuran; hexane; chloroform / 2 h / -70 - -30 °C
7.2: -70 - 20 °C
With
hydrogenchloride; sodium hydroxide; n-butyllithium; chloroformic acid ethyl ester; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; hexane; chloroform; water;
![dimethyl-(2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-yl)amine](/Databaselist/images/loading.webp)
